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Items: 3

1.

TSC22D, WNK and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation

(Submitter supplied) The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. We used gene co-essentiality analysis to identify an unappreciated relationship between TSC22D2, WNK1 and NRBP1 in regulating cell volume homeostasis. Each of these genes have paralogs and are functionally buffered for osmo-sensing and cell volume control. Within seconds of hyperosmotic stress, TSC22D, WNK and NRBP family members physically associate into biomolecular condensates, a process that is dependent on intrinsically disordered regions (IDRs). more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL16791
55 Samples
Download data: TXT
Series
Accession:
GSE269526
ID:
200269526
2.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
3.

CHEM064.WT.T13A.DMSO

Organism:
Homo sapiens
Source name:
Blood
Platform:
GPL16791
Series:
GSE269526
Download data: TXT
Sample
Accession:
GSM8319617
ID:
308319617
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db=gds|term=GSM8319617[Accession]|query=1|qty=2|blobid=MCID_674cc7f230e6852f8a87cba8|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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