GSM8435111[Accession] - GEO DataSets

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Items: 4

Select item 2002736851.

Analysis of population heterogeneity in CHO cells by genome-wide DNA methylation analysis and by multi-modal single-cell sequencing

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Cricetulus griseus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL27425
35 Samples

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Accession:: GSE273685

ID:: 200273685

Select item 2002736842.

Analysis of population heterogeneity in CHO cells by genome-wide DNA methylation analysis and by multi-modal single-cell sequencing [time series]

(Submitter supplied) CHO cells are major hosts for the industrial production of therapeutic proteins and their production stability is of considerable economic significance. It is widely known that CHO cells can rapidly acquire genetic alterations, which affects their genetic homogeneity over time. However, the role of non-genetic mechanisms, including epigenetic mechanisms such as DNA methylation, remains poorly understood. more...