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Items: 3

1.

Microglia regulate cortical remyelination via ΤNFR1-dependent phenotypic polarization [RNA-Seq]

(Submitter supplied) Microglia are strongly implicated in demyelinating neurodegenerative diseases with increasing evidence for roles in protection and healing, but the mechanisms that control CNS remyelination are poorly understood. Here we show that microglia-specific deletion of TNFR1 and pharmacological inhibition of soluble TNF (solTNF) or downstream IL-1R allow maturation of highly activated disease-associated microglia with increased size and myelin phagocytosis capacity that accelerate cortical remyelination and motor recovery. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21626
28 Samples
Download data: RESULTS
Series
Accession:
GSE278137
ID:
200278137

2.

NextSeq 550 (Mus musculus)

Organism:
Mus musculus
1398 Series
59735 Samples
Download data
Platform
Accession:
GPL21626
ID:
100021626

3.

Whole brain, TNFR1ff, naive, rep2

Organism:
Mus musculus
Source name:
whole brain
Platform:
GPL21626
Series:
GSE278137
Download data: RESULTS
Sample
Accession:
GSM8540694
ID:
308540694

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db=gds|term=GSM8540694[Accession]|query=1|qty=2|blobid=MCID_6749654c86d4ad4f7f5fccd4|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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