GSM8599125[Accession] - GEO DataSets

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Items: 4

Select item 2002811511.

Transient histone deacetylase inhibition induces cellular memory of gene expression and three-dimensional genome folding

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other

Platforms:: GPL28457 GPL28330
99 Samples

Download data: BW, MCOOL, NARROWPEAK, TSV

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Accession:: GSE281151

ID:: 200281151

Select item 2002804862.

A histone hyperacetylation pulse induces cellular memory of gene expression and 3-dimensional genome folding [ATAC-seq]

(Submitter supplied) Epigenetic memory enables the stable propagation of gene expression patterns in response to transient developmental and environmental stimuli. Although 3-dimensional (3D) organisation is emerging as a key regulator of genome function due its role in gene expression control, it is unknown whether it contributes to cellular memory. Here, we establish that acute perturbation of the epigenome can induce cellular memory of gene expression in mouse embryonic stem cells (mESCs). more...