GEO DataSets

(Submitter supplied) Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and negative regulators establishes such a tonic signal. Ligandindependent signaling by the precursors of mature antigen receptors regulates development of B- and T-lymphocytes. Here we describe a basal signal controlling gene expression profiles in the Jurkat T cell line and mouse thymocytes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2352

Platform:

GPL3084

21 Samples

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Analysis of resting Jurkat T cells and derived mutants lacking T cell receptor (TCR) signaling proteins. Even without TCR engagement, the signaling pathways normally responsive to TCR are not inert. Results provide insight into the transcriptional consequences of the constitutive signaling pathway.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 6 cell line, 2 genotype/variation, 2 protocol sets

Platform:

GPL3084

Series:

GSE3922

21 Samples

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(Submitter supplied) Material is transferred from microtiter plate wells to the slide surface by an automated print head

Organism:

Homo sapiens

1 DataSet

2 Series

34 Samples

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