GSM92148[Accession] - GEO DataSets

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Items: 4

Select item 2000040251.

Gene Expression Preferentially Regulated by Tamoxifen in Breast Cancer Cells

(Submitter supplied) The beneficial effect of the selective estrogen receptor modulator (SERM) tamoxifen in the treatment and prevention of breast cancer is assumed to be through its ability to antagonize the stimulatory actions of estrogen, although tamoxifen can also have some estrogen-like agonist effects. Here we report that in addition to these mixed agonist/antagonist actions, tamoxifen can also selectively regulate a unique set of more than 60 genes in estrogen receptor alpha (ERa)-positive MCF-7 human breast cancer cells which are minimally regulated by estradiol or raloxifene. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2367
Platform:: GPL96
17 Samples

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Series

Accession:: GSE4025

ID:: 200004025

Select item 23672.

Tamoxifen effect on breast cancer cell line expressing estrogen receptor alpha and beta

Analysis of estrogen receptor alpha (ERalpha)-positive MCF-7 breast cancer (BC) cells infected with adenovirus-ERbeta and treated with tamoxifen (Tam). Tam is a selective ER modulator used in BC prevention and treatment. Results provide insight into Tam activity in the presence of both ERs.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 agent, 2 infection sets

Platform:: GPL96
Series:: GSE4025
17 Samples

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DataSet

Accession:: GDS2367

ID:: 2367

Select item 1000000963.

[HG-U133A] Affymetrix Human Genome U133A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The U133 set includes 2 arrays with a total of 44928 entries and was indexed 29-Jan-2002. more...