GEO DataSets

(Submitter supplied) Pompe disease is a genetic disorder resulting from a deficiency of lysosomal acid alpha-glucosidase (GAA) that manifests as a clinical spectrum with regard to symptom severity and rate of progression. In this study, we used microarrays to examine gene expression from the muscle of two cohorts of infantile-onset Pompe patients to identify transcriptional differences that may contribute to the disease phenotype. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4409 GDS4410

Platform:

GPL570

58 Samples

Download data: CEL

Analysis of quadriceps biopsies from infantile-onset Pompe disease patients treated with recombinant human lysosomal acid alpha-glucosidase (rhGAA, Myozyme) for up to 52 weeks. Results provide insight into molecular mechanisms underlying the response to therapy (positive vs. poor clinical outcome).

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 2 disease state, 18 individual, 3 other, 4 time sets

Platform:

GPL570

Series:

GSE38680

39 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...

Organism:

Homo sapiens

602 DataSets

5671 Series

61 Related Platforms

175585 Samples

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