GSM96510[Accession] - GEO DataSets

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Items: 3

Select item 2000042281.

Nitric Oxide Activation of Erk Regulates the Stability and Translation of mRNA Transcripts Containing CU-Rich Elements

(Submitter supplied) Nitric oxide (NO) can stabilize mRNA by activating p38 mitogen-activated protein kinase (MAPK). Here, transcript stabilization by NO was investigated in human THP-1 cells using microarrays. After LPS pre-stimulation, cells were treated with actinomycin D and then exposed to NO without or with the p38 MAPK inhibitor SB202190. The decay of 220 mRNAs was affected; most were stabilized by NO. Unexpectedly, SB202190 often enhanced rather than antagonized transcript stability. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
56 Samples

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Accession:: GSE4228

ID:: 200004228

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000000962.

[HG-U133A] Affymetrix Human Genome U133A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The U133 set includes 2 arrays with a total of 44928 entries and was indexed 29-Jan-2002. more...