GEO DataSets

(Submitter supplied) Hepatic fibrosis is a wound-healing response to chronic liver injury, which may result in cirrhosis and liver failure. The c-Jun N-terminal kinase-1 (JNK1) gene has been shown to be involved in liver fibrosis. Here, we aimed to investigate the molecular mechanism and identify the cell-type involved in mediating the JNK1-dependent effect on liver fibrogenesis Wild-type (WT), JNK1−/− and JNK1Δhepa (hepatocyte-specific deletion of JNK1) mice were subjected to bile duct ligation (BDL). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4878

Platform:

GPL11533

24 Samples

Download data: CEL

Analysis of liver from c-Jun N-terminal kinase-1 null (Jnk1-/-) and hepatocyte-specific, JNK1 null (Jnk1Δhepa) males subjected to BDL for up to 28 days to induce liver fibrosis. Liver injury activates Jnk members of the MAPK family. Results provide insight into the role of Jnk1 in liver fibrosis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 genotype/variation, 2 protocol, 2 time sets

Platform:

GPL11533

Series:

GSE40041

24 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html MoGene-1_1-st-v1.na31.mm9.transcript.csv #%create_date=Fri Aug 27 17:50:02 2010 PDT #%chip_type=MoGene-1_1-st-v1 #%lib_set_name=MoGene-1_1-st #%lib_set_version=v1 #%genome-species=Mus musculus #%genome-version=mm9 #%genome-version-ucsc=mm9 #%genome-version-ncbi=37 #%genome-version-create_date=2007-07-00 #%genome-lifted-method=liftOver #%genome-lifted_from-species=Mus musculus #%genome-lifted_from-version-ucsc=mm8 #%genome-lifted_from-version-ncbi=36 #%netaffx-annotation-date=2010-07-15 #%netaffx-annotation-netaffx-build=31 Protocol: see manufacturer's web site

Organism:

Mus musculus

10 DataSets

174 Series

7 Related Platforms

4230 Samples

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