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    Items: 3

    1.

    Analyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

    (Submitter supplied) For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics are highly desired. In the present study, the transcriptomics responses following exposure to genotoxic (GTX) and non-genotoxic (NGTX) hepatocarcinogens and non-carcinogens (NC) in five liver-based in vitro models, namely conventional and epigenetically-stabilized cultures of primary rat hepatocytes, the human hepatoma-derived HepaRG and HepG2 cell lines and the human embryonic stem cell-derived hepatocyte-like cells hES-Heps are examined and compared.
    Organism:
    Homo sapiens; Rattus norvegicus
    Type:
    Expression profiling by array
    Platforms:
    GPL13916 GPL15933
    548 Samples
    Download data: CEL
    Series
    Accession:
    GSE40117
    ID:
    200040117

    PubMed Similar studies Analyze with GEO2R

    2.

    [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray ENSG Version 14.1]

    (Submitter supplied) see manufacturer's protocol
    Organism:
    Homo sapiens
    4 Series
    1 Related Platform
    725 Samples
    Download data: TAR
    Platform
    Accession:
    GPL13916
    ID:
    100013916

    3.

    hES-Heps-SPB -72h rep2

    Organism:
    Homo sapiens
    Source name:
    human embryonic stem cell derived hepatocyte like cells
    Platform:
    GPL13916
    Series:
    GSE40117
    Download data: CEL
    Sample
    Accession:
    GSM985478
    ID:
    300985478

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