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Items: 3

1.

Analyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

(Submitter supplied) For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics are highly desired. In the present study, the transcriptomics responses following exposure to genotoxic (GTX) and non-genotoxic (NGTX) hepatocarcinogens and non-carcinogens (NC) in five liver-based in vitro models, namely conventional and epigenetically-stabilized cultures of primary rat hepatocytes, the human hepatoma-derived HepaRG and HepG2 cell lines and the human embryonic stem cell-derived hepatocyte-like cells hES-Heps are examined and compared.
Organism:
Rattus norvegicus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL13916 GPL15933
548 Samples
Download data: CEL
Series
Accession:
GSE40117
ID:
200040117

PubMed Similar studies Analyze with GEO2R

2.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray ENSG Version 14.1]

(Submitter supplied) see manufacturer's protocol
Organism:
Homo sapiens
4 Series
1 Related Platform
725 Samples
Download data: TAR
Platform
Accession:
GPL13916
ID:
100013916

3.

HepG2-WYE-72h rep3

Organism:
Homo sapiens
Source name:
HepG2 cell line
Platform:
GPL13916
Series:
GSE40117
Download data: CEL
Sample
Accession:
GSM985729
ID:
300985729

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db=gds|term=GSM985729[Accession]|query=1|qty=3|blobid=MCID_674c388996d9ad040621fe31|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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