GSM991000[Accession] - GEO DataSets

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Items: 4

Select item 2000402961.

Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development

(Submitter supplied) In the developing brain, neural progenitor cells (NPCs) switch the differentiation competency via changing gene expression profiles that are governed partly by epigenetic control such as histone modification, although the precise mechanism is unknown. Here we found that ESET/Setdb1/KMT1E, a histone H3 Lys-9 (H3K9) methyltransferase, was highly expressed at early stages of brain development but down-regulated over time, and that ablation of ESET led to decreased H3K9 trimethylation and misregulation of genes, resulting in severe brain defects and early lethality. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4508
Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE40296

ID:: 200040296

Select item 45082.

Histone methyltransferase ESET knockout effect on embryonic dorsal telencephalon

Analysis of dorsal telencephalon from E14.5 embryos depleted of histone methyltransferase ESET. ESET ablation leads to decreased H3K9 trimethylation and misregulation of genes resulting in severe brain defects and embryonic lethality. Results provide insight into role of ESET in brain development.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE40296
6 Samples

Download data: CEL

DataSet

Accession:: GDS4508

ID:: 4508

Select item 1000012613.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...