GEO DataSets

(Submitter supplied) Cytokines have been shown to play a key role in the destruction of beta cells. In the rat insulinoma cell line (INS-1ab) overexpressing pancreatic duodenum homeobox 1 (Pdx1) increases sensitivity to Interleukin 1b (IL-1b). To elucidate mechanisms of action underlying Pdx1 driven potentiation of beta-cell sensitivity to IL-1β, we performed a microarray analysis of INS-1ab cells with and without Pdx1 overexpression exposed to IL-1β between 2h and 24h.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4332

Platform:

GPL1355

56 Samples

Download data: CEL

Analysis of pancreatic duodenum homeobox 1 (Pdx1)-overexpressing, INS-1ab insulinoma cell line exposed to Interleukin 1b (IL-1β) cytokine for up to 24 hrs. Results provide insight into the molecular mechanisms underlying Pdx1-driven potentiation of beta cell sensitivity to IL-1β.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 2 genotype/variation, 5 time sets

Platform:

GPL1355

Series:

GSE40642

56 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Rat Genome 230 2.0 Array is a powerful tool for toxicology, neurobiology, and other applications using rat as a model organism. more...

Organism:

Rattus norvegicus

107 DataSets

750 Series

13 Related Platforms

23059 Samples

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