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Competitive Inhibition and Mutualistic Growth in Polymicrobial Infections: Deciphering Staphylococcus aureus – Acinetobacter baumannii Interaction Dynamics

(Submitter supplied) Staphylococcus aureus (Sa) and Acinetobacter baumannii (Ab) are frequently co-isolated from polymicrobial infections that are severe and recalcitrant to therapy. Here, we apply a combination of wet-lab experiments and in silico modeling to unveil the intricate nature of the Ab/Sa interaction using both, representative laboratory strains and strains co-isolated from clinical samples. This comprehensive methodology allowed uncovering Sa's capability to exert a partial interference on Ab by the expression of phenol-soluble modulins. more...
Organism:
Acinetobacter baumannii A118; Staphylococcus aureus subsp. aureus USA300
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL34012 GPL29525
16 Samples
Download data: TXT, XLSX
Series
Accession:
GSE250252
ID:
200250252

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