GEO DataSet Links for BioProject (Select 107577) - GEO DataSets

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Items: 2

Select item 2000107021.

Gene expression profile of cervical and skin tissues from HPV 16 E6 transgenic mice

(Submitter supplied) Background The in vivo properties of HR-HPV E6 and E7 oncoproteins have been previously evaluated through the generation and characterization of HPV transgenic mouse strains. Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17β-estradiol. Taken together, these findings suggest that E6 performs critical functions in normal adult cervix and skin, highlighting the need to define E6-controlled transcriptional programs in these tissues. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3530
Platform:: GPL8321
8 Samples

Download data: CEL, CHP

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Accession:: GSE10702

ID:: 200010702

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 35302.

Human Papillomavirus type 16 E6 transgenic model (K14E6): cervical and skin tissues

Analysis of cervix and skin from 6 week-old, virgin, transgenic females expressing HPV16 E6 oncoprotein. K14E6 transgenics present a more aggressive phenotype in the skin than in the cervix. Results provide insight into the molecular basis for this observed difference in E6 effect.