GEO DataSet Links for BioProject (Select 117749) - GEO DataSets

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Items: 2

Select item 2000170091.

Onconase Responsive Genes in Human Mesothelioma Cells: Implications for an RNA Damaging Therapeutic Agent

(Submitter supplied) Onconase represents a new class of RNA-damaging drugs. Mechanistically, Onconase is thought to internalize, where it degrades intracellular RNAs such as tRNA and double-stranded RNA, and thereby suppresses protein synthesis. However, there may be additional or alternative mechanism(s) of action. Microarray analysis was used to compare gene expression profiles in untreated human malignant mesothelioma (MM) cell lines and cells exposed to 5 ug/ml Onconase for 24 h.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3759
Platform:: GPL570
6 Samples

Download data: CEL, CHP

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Accession:: GSE17009

ID:: 200017009

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 37592.

Onconase effect on mesothelioma cells in vitro

Analysis of malignant mesothelioma (MM) cell lines (M25, M29, and M49) exposed to Onconase for 24 hrs. Onconase, an RNA damaging therapeutic agent, induces apoptosis in MM cells. Results provide insight into the molecular mechanisms underlying Onconase action in MM.