GEO DataSet Links for BioProject (Select 128361) - GEO DataSets

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Items: 2

Select item 2000226061.

Identification of an SRF- and androgen-dependent gene signature in prostate cancer

(Submitter supplied) The androgen receptor (AR) is the principal target for treatment of non-organ confined prostate cancer (PCa). Systems and bioinformatics approaches suggest that considerable variation exists in the mechanisms by which AR regulates expression of effector genes and point towards a role for secondary transcription factors (TFs) therein. We identified a novel indirect mechanism of androgen action in which effects of androgens on PCa cells are mediated by Serum Response Factor (SRF). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3861
Platform:: GPL570
12 Samples

Download data: CEL

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Accession:: GSE22606

ID:: 200022606

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 38612.

Synthetic androgen R1881 effect on transcription factor SRF-deficient prostate cancer cells

Analysis of LNCaP androgen-sensitive prostate adenocarcinoma cells, SRF (serum response factor)-silenced and treated with synthetic androgen R1881. Effects of androgens on prostate cancer (PCa) cells can be mediated by SRF. Results provide insight into targets for androgen action in PCa cells.