GEO DataSet Links for BioProject (Select 146063) - GEO DataSets

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Items: 2

Select item 2000312511.

Expression data from mouse heart deficient of HDAC3

(Submitter supplied) Gene expression changes in the heart of MCH3-KO mouse (HDAC3 f/f, Muscle Creatine Kinase-Cre) versus control WT mouse (HDAC3 f/f). Histone deacetylases (HDACs) play important roles in cardiac development and function. We show here that mice deficient of HDAC3 in heart and skeletabl muscle are relatively normal on normal chow, but develop hypertrophic cardiomyopathy and heart failure that leads to death on high-fat diet. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4886
Platform:: GPL6246
8 Samples

Download data: CEL

Series

Accession:: GSE31251

ID:: 200031251

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 48862.

Histone deacetylase 3 deficiency effect on the heart

Analysis of hearts of 6 week old mutants deleted for histone deacetylase 3 (HDAC3). HDAC3 deletion occurred 7 days after birth. These MCH3-KO mutants are viable on normal chow but a high fat diet is lethal. The results underscore the impact gene-diet interactions may have on cardiovascular health.