GEO DataSet Links for BioProject (Select 245196) - GEO DataSets

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Items: 3

Select item 2000570021.

Mutant IDH inhibits HNF4a to disrupt hepatocyte differentiation and promote cholangiocarcinoma.

(Submitter supplied) Gene expression of mouse hepatoblasts (HBs) expressing IDH1 WT, IDH1 R132C, IDH2 WT, R172K and empty vector controls (N=2 cultures for each condition) grown on collagen-coated plates and IDH1 R132C and empty vector controls on uncoated plates were evaluated using Affymetrix Mouse 430Av2 DNA microarrays that were processed at the Dana-Farber Cancer Institute core facility (http://macf-web.dfci.harvard.edu/) using their standard protocol. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS5676 GDS5677
Platform:: GPL8321
14 Samples

Download data: CEL

Series

Accession:: GSE57002

ID:: 200057002

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 56772.

Mutant isocitrate dehydrogenase 1 effect on hepatoblasts grown on uncoated plates

Analysis of mutant IDH1 (R132C)-expressing hepatoblasts that were grown on uncoated plates to induce hepatocyte differentiation. IDH genes are frequently mutated in intrahepatic cholangiocarcinoma (IHCC). Results provide insight into the role of IDH1 in hepatocyte differentiation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL8321
Series:: GSE57002
4 Samples

Download data: CEL

DataSet

Accession:: GDS5677

ID:: 5677

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56763.

Mutant isocitrate dehydrogenase 1 and 2 effect on hepatoblasts grown on collagen-coated plates

Analysis of hepatoblasts expressing mutant IDH1 (R132C) and mutant IDH2 (R172K) grown on collagen-coated plates. IDH genes are frequently mutated in intrahepatic cholangiocarcinoma (IHCC). Results provide insight into molecular pathways by which IDH mutations lead to tumor formation.