Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli - - GEO DataSets

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Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli

(Submitter supplied) In Mycobacterium tuberculosis, the PhoPR two-component regulatory system controls production and secretion of proteins and lipid virulence effectors. Several mutations, present in phoR of Mycobacterium canettii relative to M. tuberculosis, impact the expression of the PhoP regulon and the pathogenicity of the strains. Here, we analyse by RNA-seq the expression profile of PhoP-regulated genes between the two M. more...

Organism:: Mycobacterium tuberculosis; Mycobacterium canetti

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL33344 GPL33345
12 Samples

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Accession:: GSE229680

ID:: 200229680

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