GEO DataSets

Analysis of strain fer-15(b26);fem-1(hc17) young adults exposed for up to 8 hrs to pathogenic Pseudomonas aeruginosa strain PA14, less pathogenic PA14 mutant gacA, and E. coli strain OP50 (normal food source). Results provide insight into the molecular basis of the response to a bacterial pathogen.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 3 infection, 2 time sets

Platform:

GPL200

Series:

GSE5793

18 Samples

Download data: CEL

Analysis of nuo-6;ced-4 double mutants. ced-4 mutation in the intrinsic apoptosis signaling pathway suppresses the longevity of electron transport chain mutant nuo-6. Results provide insight into molecular mechanisms underlying lifespan expansion.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:

GPL200

Series:

GSE54024

13 Samples

Download data: CEL

Analysis of isp-1;ced-4 double mutants. ced-4 mutation in the intrinsic apoptosis signaling pathway suppresses the longevity of electron transport chain mutant isp-1. Results provide insight into molecular mechanisms underlying lifespan expansion.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:

GPL200

Series:

GSE54024

13 Samples

Download data: CEL

Analysis of wildtype worms treated with the pro-oxidant paraquat and electron transport chain mutants isp-1 and nuo-6. Results provide insight into common molecular mechanisms underlying the increased longevity in all three conditions.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 genotype/variation, 3 protocol sets

Platform:

GPL200

Series:

GSE54024

13 Samples

Download data: CEL

Analysis of day 8 germline-deficient glp-1 mutants treated with ash-2 RNAi. The ASH-2 trithorax complex trimethylates histone H3 at lysine 4 (H3K4); an intact germline is required for ASH-2-induced lifespan extension. Results provide insight into the role of histone methylation in longevity.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:

GPL200

Series:

GSE30505

11 Samples

Download data: CEL

Analysis of adult worms fed live lactic acid bacteria (LAB) Lactobacillus rhamnosus CNCM I-3690 or CNCM I-4317 for 10 days. L. rhamnosus CNCM I-3690 protects against oxidative stress and increases lifespan in worms. Results provide insight into probiotic LAB-induced oxidative stress protection.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL200

Series:

GSE42192

9 Samples

Download data: CEL

Analysis of N2 young adults after 4hr exposure to live or heat-killed C. albicans DAY185. C. albicans hyphae can kill C. elegans in a manner modeling key aspects of mammalian pathogenesis. Results provide insight into molecular mechanisms underlying host immune response to C. albicans infection.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 3 infection sets

Platform:

GPL200

Series:

GSE27401

9 Samples

Download data: CEL, TXT

Analysis of day 2 germline-deficient glp-1 mutants treated with ash-2 RNAi. The ASH-2 trithorax complex trimethylates histone H3 at lysine 4 (H3K4); an intact germline is required for ASH-2-induced lifespan extension. Results provide insight into the role of histone methylation in longevity.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:

GPL200

Series:

GSE30505

12 Samples

Download data: CEL

Analysis of tdp-1(ok803lf) mutants. TDP-1 loss alleviates proteotoxicity and extends life span. Results provide insight into a role for TDP-1 in the regulation of protein homeostasis and aging.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL200

Series:

GSE34113

6 Samples

Download data: CEL

Analysis of age-synchronized L3 nematodes exposed to LC10 of gold nanoparticles (Au-NPs). The Au-NPs are used as a model for studying particle-specific effects of manufactured nanomaterials (MNMs). Results provide insight into in vivo particle-specific toxicity of Au-NPs to C. elegans.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL200

Series:

GSE32521

6 Samples

Download data: CEL

Analysis of atfs-1 mutants raised on spg-7(RNAi) which induces mitochondrial stress (MS). ATFS-1 (activating transcription factor associated with stress-1) senses MS and communicates with the nucleus during the mitochondrial unfolded protein response. Results provide insight into the MS response.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 2 genotype/variation, 2 protocol sets

Platform:

GPL200

Series:

GSE38196

12 Samples

Download data: CEL, CHP

Analysis of kgb-1 mutants incubated with 1mM copper sulfate for 1hr. The conserved KGB-1 JNK mitogen-activated protein kinase pathway regulates the response to heavy metal stress. Results provide insight into molecular mechanisms underlying the heavy metal stress response.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 2 genotype/variation, 2 stress sets

Platform:

GPL200

Series:

GSE42703

4 Samples

Download data: CEL, CHP

Analysis of young worms fed live lactic acid bacteria (LAB) Lactobacillus rhamnosus CNCM I-3690 or CNCM I-4317 for 3 days. L. rhamnosus CNCM I-3690 protects against oxidative stress and increases lifespan in worms. Results provide insight into probiotic LAB-induced oxidative stress protection.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL200

Series:

GSE42192

9 Samples

Download data: CEL

Analysis of heme-cultured HRG-2 mutants. Heme-responsive gene-2 (HRG-2) is a hypodermal, heme-binding, type I membrane protein; cytochrome distribution is abnormal in HRG-2-deficient worms. Results provide insight into molecular mechanisms underlying the regulation of heme homeostasis by HRG-2.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:

GPL200

Series:

GSE34471

12 Samples

Download data: CEL, CHP

Analysis of xpa-1 mutants deficient in nucleotide excision repair (NER). Transcription-blocking DNA damage is believed to contribute to aging and underlie activation of oxidative stress responses (OSR). Results provide insight into the transcriptomic reprogramming response in xpa-1 mutants.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL200

Series:

GSE39252

10 Samples

Download data: CEL

Analysis of bacterial infected C. elegans treated with 70 μM RPW-24 or DMSO. In a C.elegans-bacterial infection assay screening small molecules, RPW-24 was identified as a putative antimicrobial agent. Results provide insight into C. elegans conserved immune response to bacterial infection.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL200

Series:

GSE37266

6 Samples

Download data: CEL

Analysis of C.elegans at 3 points during aging: late larval L4 stage, days 6 and 15 of adulthood. C. elegans exhibits increased susceptibility to bacterial infection with age. Results provide insight into molecular mechanisms underlying the decline in immune function with aging (immunosenescence).

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 age, 2 development stage sets

Platform:

GPL200

Series:

GSE21784

9 Samples

Download data: CEL

Analysis of fer-1 loss of function C. elegans mutants. The fer-1 gene encodes a homolog for the human Dysferlin gene. Mutations in the human Dysferlin gene results in Limb Girdle Muscular Dystrophy 2B (LGMD2B). Results provide insight into the molecular pathogenesis of LGMD2B.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL200

Series:

GSE16753

12 Samples

Download data: CEL

Analysis of 8 different electron transport chain (ETC) subunit mutants (3 missense and 5 RNAi-induced) in complexes I, II, and III. Results from this validation set provide insight into the contributions of individual complexes or subunits to primary mitochondrial dysfunction.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 4 genotype/variation, 4 protocol sets

Platform:

GPL200

Series:

GSE9897

10 Samples

Download data: CEL

Analysis of gas-1(fc21) electron transport chain complex I mutants. The gas-1(fc21) mutation affects the 49 kD subunit of complex I, decreasing the rate of complex I-dependent oxidative phosphorylation. Results provide insight into molecular mechanisms underlying primary mitochondrial disease .

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL200

Series:

GSE9896

10 Samples

Download data: CEL