GEO DataSets

Analysis of acute myelogenous leukemia (AML) leukemia stem cells (LSC) induced either by Hoxa9/Meis1a oncogenes or MLL-AF9 oncoprotein. LSC self-renewal pathway in myeloid cells is central to AML development. Results provide insight into the molecular mechanisms underlying development of LSC in AML.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 cell line, 5 cell type, 2 disease state sets

Platform:

GPL8321

Series:

GSE20377

15 Samples

Download data: CEL

Analysis of mutant IDH1 (R132C)-expressing hepatoblasts that were grown on uncoated plates to induce hepatocyte differentiation. IDH genes are frequently mutated in intrahepatic cholangiocarcinoma (IHCC). Results provide insight into the role of IDH1 in hepatocyte differentiation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL8321

Series:

GSE57002

4 Samples

Download data: CEL

Analysis of hepatoblasts expressing mutant IDH1 (R132C) and mutant IDH2 (R172K) grown on collagen-coated plates. IDH genes are frequently mutated in intrahepatic cholangiocarcinoma (IHCC). Results provide insight into molecular pathways by which IDH mutations lead to tumor formation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 genotype/variation sets

Platform:

GPL8321

Series:

GSE57002

10 Samples

Download data: CEL

Analysis of RCAS PDGFB/Nestin tv-A glioma cells from Ptprd knockout and Cdkn2a/p16Ink4a knockout mice. PTPRD is a tumor suppressor of glioma that is often co-deleted with tumor suppressor p16INK4A. Results provide insight into the cooperative effects of PTPRD and p16INK4A loss in gliomagenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL8321

Series:

GSE55061

7 Samples

Download data: CEL

Analysis of adipose tissue from two subcutaneous depots (inguinal and axillary) and two visceral depots (epididymal and mesenteric) from age-matched, C57Bl/6 males. SubQ and VISC represent two broad categories of obesity. Results provide insight into fat depot-specific molecular profiles.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 other, 2 tissue sets

Platform:

GPL8321

Series:

GSE53307

12 Samples

Download data: CEL

Analysis of Ba/F3 cells expressing a constitutively active form of PDGFRα or PDGFRβ oncogene (Fip1L1-PDGFRα or TEL-PDGFRβ) and treated with imatinib (Glivec), a potent PDGFR inhibitor. Results provide insight into target genes of the PI3K/PKB/FOXO pathway downstream of growth factor stimulation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 genotype/variation, 2 growth protocol sets

Platform:

GPL8321

Series:

GSE44810

6 Samples

Download data: CEL, CHP, DAT, XML

Analysis of pancreatic beta cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5502, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL8321

Series:

GSE31102

6 Samples

Download data: CEL

Analysis of pancreatic alpha cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5503, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL8321

Series:

GSE31102

6 Samples

Download data: CEL

Analysis of mammary tumors from mutants lacking stem cell antigen-1 (Sca-1), a glycerophosphatidylinositol-anchored protein. Tumorigenesis induced by medroxyprogesterone and 7,12dimethylbenz(a)anthracene treatment. Results provide insight into the role of Sca-1 in mammary gland tumorigenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL8321

Series:

GSE31954

4 Samples

Download data: CEL

Analysis of osteoclasts lacking the transcription factor NFATc1. Osteoclasts cultured in the presence of M-CSF and RANKL to induce differentiation. Results identify gene targets of NFATc1 in osteoclastogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL8321

Series:

GSE37219

4 Samples

Download data: CEL

Analysis of hypothalamus from streptozotocin-induced diabetic males (a model of insulin-deficient, type 1 diabetes). The hypothalamus controls the endocrine system, appetite and energy balance. Results provide molecular insight into how diabetes affects hypothalamic function.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL8321

Series:

GSE62013

17 Samples

Download data: CEL

Analysis of E14.5 cerebral cortex, Caveolin-1 (Cav-1) deficient, cultured neurospheres treated with glucocorticoid (GC) dexamethasone (100nM, 4h). Cav-1 involved in GC signaling in neural stem cells. Results provide insight into role of Cav-1 in GC treatment and impact fetal brain development.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL8321

Series:

GSE49804

20 Samples

Download data: CEL

Analysis of regulatory T (Treg) cells from mutants deficient for the transcription factor GATA-3. GATA-3 forms a complex with the transcription factor Fox3p, essential in the function of Treg cells. Results provide insight into the role of GATA-3 in the regulation of the Treg transcriptome.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL8321

Series:

GSE39864

6 Samples

Download data: CEL

Analysis of hearts of C57BL/6 animals infected with the intracellular parasite Trypanosoma cruzi. T. cruzi causes Chagas disease which can lead to cardiomyopathy. Results provide insight into the molecular mechanisms underlying the innate immune response in the heart to T. cruzi infections.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 infection sets

Platform:

GPL8321

Series:

GSE41089

6 Samples

Download data: CEL, CHP

Analysis of F424a adipocytes overexpressing an active spliced form of X-box binding protein 1 (XBP1). XBP is a transcription factor involved in the unfolded protein response. Results provide insight into the function of XBP1 in adipocytes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL8321

Series:

GSE46178

8 Samples

Download data: CEL

Analysis of PDA tumors isolated from KPC (LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre) mice after combined treatment with FG-3019 (a mAb directed against CTGF) and chemotherapy drug gemcitabine. Results provide insight into the molecular basis of the enhanced anti-PDA activity of FG-3019/gemcitabine.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 protocol sets

Platform:

GPL8321

Series:

GSE46203

24 Samples

Download data: CEL

Analysis of liver from hepatocyte-specific, thioredoxin reductase 1 (TrxR1)-null mutants treated with the pro-toxin acetaminophen. The Trx system impacts bioenergetics and drug metabolism. Results provide insight into the role of the Trx system in detoxifying certain xenobiotic challenges.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:

GPL8321

Series:

GSE37874

12 Samples

Download data: CEL

Analysis of MyoD-derived sarcomas derived from MDKP (MyoDCE/+; LSL-KrasG12D/+;Trp53Fl/Fl) mice and histological variants (UPS, pleomorphic RMS, and embryonal RMS) from P7KP (Pax7CE/+;LSL-KrasG12D/+;Trp53Fl/Fl) mice. Results provide insight into molecular differences underlying the sarcoma subtypes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 disease state, 2 genotype/variation sets

Platform:

GPL8321

Series:

GSE46836

27 Samples

Download data: CEL

Analysis of brains deficient for SIRT1. SIRT1 is an NAD-dependent protein deacetylase that play a role in numerous metabolic processes in many tissues, including the brain. Results provide insight into the impact of SIRT1 on brain physiology.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL8321

Series:

GSE28790

8 Samples

Download data: CEL

Analysis of the soleus muscles of transcription factor Yin Yang 1 (YY1) deficient animals. Many nuclear genes encoding mitochondrial proteins contain binding sites for YY1 in their proximal promoters. Results provide insight into the role of YY1 in mitochondrial function.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL8321

Series:

GSE39009

7 Samples

Download data: CEL