GEO DataSets

Expression profiling of contused spinal cords of Fischer animals. Spinal cords examined 35 days following contusion at the thoracic 8 segment. Results identify potential targets for therapeutic intervention following spinal cord injury.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 shock sets

Platform:

GPL85

Series:

GSE2599

6 Samples

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(Submitter supplied) Excerpt from a larger study which characterized the transcriptional effects of a spinal cord contusion injury in rats. This is the data from the almost chronic contusion state (35 days) at the injury site (Thoracic 8) - where we saw significant changes in several areas, including cholesterol metabolism genes. Other spinal cord areas (rostral, caudal) and time-points (3 hours, 24 hours, 7 days and 35 days) were analyzed as well and are discussed in our paper and at www.crpf.org/microarray. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1238

Platform:

GPL85

6 Samples

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(Submitter supplied) Type of experiment: Comparison of liver samples between sham (control) and 20% TBSA (total burn surface area) burn rats collected at 1h, 4h, 8h, and 24h. Experimental factors: Burn injury and time Experiment design: All experimental liver samples collected after 1h, 4h, 8h, and 24h after burn injury were compared to a common reference (sham control treated as 0h time point) Bio source: Sprague-Drawley male rats weighing 150-200 g supplied through Charles river laboratories, MA (www.criver.com) Bio material manipulations: Rats (n=3 for each scald-burn and sham-burn time point) were individually housed in a temperature-controlled (25oC) and light-controlled room (12h light-dark cycle) and allowed to adjust to their new surroundings for at least 5 days prior to the experiment. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS599

Platform:

GPL85

10 Samples

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Temporal analysis of metabolic and inflammatory response to burn injury. Livers from male Sprague-Dawleys examined at 1, 4, 8, and 24 hours following 20% total burn surface area scald-burn injury.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 time sets

Platform:

GPL85

Series:

GSE802

10 Samples

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(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) Previously, we demonstrated using a rat model of spinal cord injury (SCI) that bladder wall tissue compliance significantly increased within the first 2 weeks following injury. In order to explore the potential molecular-level mechanisms of this event, the present study quantified molecules pertinent to bladder tissue remodeling and changes in mechanical properties. An initial gene array analysis followed by real-time qPCR revealed that the message levels for tropoelastin and lysyl oxidase were as high as 8-fold in SCI rats compared to normal. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3507

Platform:

GPL85

4 Samples

Download data: CEL, CHP

Analysis of bladders from Sprague-Dawley females for up to 25 days following spinal cord injury (SCI). Bladder wall tissue compliance increases within 2 weeks after SCI in this animal model. Results provide insight into the molecular basis of the changes that the bladder undergoes after SCI.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state, 4 time sets

Platform:

GPL85

Series:

GSE14096

4 Samples

Download data: CEL, CHP

(Submitter supplied) cDNA microarray study of gene expression changes in whole blood from LPS treated rats, 2 and 6 hours after I.P. injection of 5 mg/kg Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1344

12 Samples

Download data: TIFF