GEO DataSets

Analysis of renal tumors from 34 papillary renal cell carcinoma (PRCC) cases. Results identify 2 molecular signatures that correlate with the morphologic classification of PRCC. Molecular class type 1 tumors correlate with excellent survival, while type 2 tumors correlate with poor survival.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 disease state, 2 other sets

Platform:

GPL570

Series:

GSE2748

34 Samples

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(Submitter supplied) BACKGROUND: Despite the moderate incidence of papillary renal cell carcinoma (PRCC), there is a disproportionately limited understanding of its underlying genetic programs. There is no effective therapy for metastatic PRCC, and patients are often excluded from kidney cancer trials. A morphological classification of PRCC into Type 1 and Type 2 tumors has been recently proposed, but its biological relevance remains uncertain. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1344

Platform:

GPL570

34 Samples

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(Submitter supplied) Myc oncogenic signature in Papillary type 2b Keywords: Gene Expression experiment

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4866

47 Samples

Download data: CEL

(Submitter supplied) Our goal was to identify gene expression features, using comprehensive gene expression profiling, that correlate with survival in conventional renal cell carcinomas (cRCCs). We profiled 177 cRCCs using high-density cDNA microarrays. Unsupervised hierarchical clustering analysis segregated cRCC into five gene expression subgroups. Expression subgroup was correlated with survival in long-term follow-up and was independent of grade, stage, and performance status. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

10 related Platforms

177 Samples

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(Submitter supplied) In order to address the progression, metastasis, and clinical heterogeneity of renal cell cancer (RCC), transcriptional profiling with oligonucleotide microarrays (22,283 genes) was done on 49 RCC tumors, 20 non-RCC renal tumors, and 23 normal kidney samples. Samples were clustered based on gene expression profiles and specific gene sets for each renal tumor type were identified. Gene expression was correlated to disease progression and a metastasis gene signature was derived. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

92 Samples

Download data: CEL, TXT

(Submitter supplied) Genetic lesions characteristic for RCC subtypes can be identified by virtual karyotyping with SNP microarrays. In this study, we examined whether virtual karyotypes could be used to better classify a cohort of morphologically challenging/unclassified RCC.

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platforms:

GPL2641 GPL3718

120 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

295 Samples

Download data: CEL, CSV

(Submitter supplied) We used microarrays to profile the expression levels of 285 ovarian samples in order to identify molecular subtypes of the tumour Keywords: disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

285 Samples

Download data: CEL, CSV

(Submitter supplied) We used microarrays to profile the expression levels of 5 tumour samples Keywords: expression difference of cell types in tumour samples

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

10 Samples

Download data: CEL, CSV

(Submitter supplied) Between 80% and 90% of renal carcinomas are either clear cell renal cell carcinoma or papillary RCC although there are at least 20 other distinct forms of RCC recognised by the World Health Organization (WHO). Emerging or provisional entities have been considered as variants of PRCC, including papillary renal neoplasm with reversed polarity (PRNRP). However, the molecular basis of PRNRP, and miRNA expression profile, is unknown. more...

Organism:

synthetic construct; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL21572

10 Samples

Download data: CEL, CHP

(Submitter supplied) Between 80% and 90% of renal carcinomas are either clear cell renal cell carcinoma or papillary RCC although there are at least 20 other distinct forms of RCC recognised by the World Health Organization (WHO). Emerging or provisional entities have been considered as variants of PRCC, including papillary renal neoplasm with reversed polarity (PRNRP). However, the molecular basis of PRNRP is unknown. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24539

17 Samples

Download data: CEL, CHP

(Submitter supplied) Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade renal neoplasm with morphological characteristics mimicking both clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC). However, despite some overlapping features, their morphological, immunohistochemical, and molecular profiles are distinct. To better understand the biology of this tumor, we analyze the miRNA expression profiles of a set of CCPRCC by microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16770

8 Samples

Download data: TXT

(Submitter supplied) MicroRNAs play a vital role in the process of tumorigenesis. To identify and characterize miRNA Expression in renal cell cancer, we performed microarray based screening of miRNA expression profiles in clear cell, papillary type 1 and papillary type 2 renal cell cancer.

Organism:

Homo sapiens; synthetic construct

Type:

Non-coding RNA profiling by array

Platform:

GPL8786

38 Samples

Download data: CEL

(Submitter supplied) We applied scATAC-seq to construct a cell type-specific epigenetic landscape of kidney at single-cell resolution.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL24676 GPL18573

2 Samples

Download data: BED, CSV, RDS

(Submitter supplied) In this study, 19 tumor samples from patients with renal cell carcinoma (RCC)-end-stage renal disease (ESRD) were analyzed by array comparative genomic hybridization (array CGH) using the Agilent Whole Human Genome 4× Array.

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL8841

19 Samples

Download data: TXT

(Submitter supplied) In this study, eighty tumor samples from 63 patients with renal cell carcinoma (RCC)-end-stage renal disease (ESRD) were analyzed by array comparative genomic hybridization (array CGH) using the Agilent Whole Human Genome 4×44K Oligo Micro Array.

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL5477

79 Samples

Download data: TXT

(Submitter supplied) Renal epithelial neoplasms have characteristic chromosomal imbalances that can be used for classification. We have previously shown that virtual karyotypes (v-karyotype) derived from SNP microarrays can be performed on formalin-fixed paraffin embedded (FFPE) tissue samples but a direct comparison with karyotypes obtained by conventional cytogenetics has not been done. 20 archival FFPE tumor samples were analyzed with Affymetrix 10K 2.0 or 250K Nsp SNP microarrays.

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platforms:

GPL2641 GPL3718

19 Samples

Download data: CEL, CHP

(Submitter supplied) Each total RNA sample is hybridized to two different arrays: Affymetrix U133A (GPL96) and U133B (GPL97). For most of the normal tissue samples there is a renal clear cell carcinoma sample from the same patient. There is no matching tumor sample for normal sample N1. For most of the renal clear cell carcinoma samples there is a corresponding adjacent normal tissue sample from the same patient. There are no matching normal tissue samples for C011 or C032. Keywords = kidney Keywords = renal Keywords = RCC Keywords = carcinoma Keywords = cancer Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS505 GDS507

Platforms:

GPL96 GPL97

34 Samples

Download data: CEL

Investigation into mechanisms of renal clear cell carcinogenesis (RCC). Comparison of renal clear cell tumor tissue and adjacent normal tissue isolated from the same surgical samples.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 10 individual sets

Platform:

GPL97

Series:

GSE781

17 Samples

Download data: CEL

Investigation into mechanisms of renal clear cell carcinogenesis (RCC). Comparison of renal clear cell tumor tissue and adjacent normal tissue isolated from the same surgical samples.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 10 individual sets

Platform:

GPL96

Series:

GSE781

17 Samples

Download data: CEL