Similar studies for GEO DataSets (Select 1621) - GEO DataSets

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Items: 2

Select item 16211.

c-Jun N-terminal kinase pathway activation and suppression effect on aortic vascular smooth muscle cells

Analysis of aortic vascular smooth muscle cells following c-Jun N-terminal kinase (JNK) activation or JNK suppression with H202 treatment to induce oxidative stress (OS). OS is linked to abdominal aortic aneurysm (AAA) and activates JNK. Results provide insight into the role of JNK in AAA.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 4 agent, 2 stress sets

Platform:: GPL85
Series:: GSE2190
6 Samples

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Accession:: GDS1621

ID:: 1621

Select item 2000021902.

JNK-dependent genes_rVSMC

(Submitter supplied) Oxidative stress-dependent genes are defined as those induced or suppressed by H2O2 treatement in rat vascular smooth muscle cells. JNK-induced genes in rat vascular smooth muscle cells are defined as those induced by adenoviruses encoding constitutively active MKK7 (caMKK7) + wild type JNK1 (wtJNK1) and suppressed by adenovirus encoding dominant negative JNK1 (APF). JNK-suppressed genes in rat vascular smooth muscle cells are defined as those suppressed by adenoviruses encoding constitutively active MKK7 (caMKK7) + wild type JNK1 (wtJNK1) and induced by adenovirus encoding dominant negative JNK1 (APF). more...