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Links from GEO DataSets

Items: 17

1.
Full record GDS1700

Anemia induced by acute renal rejection: peripheral blood lymphocytes

Analysis of peripheral blood lymphocytes from 4 renal allograft recipients with acute rejection and concurrent anemia. Compromised renal function after renal allograft transplantation often results in anemia. Results provide insight into the molecular events underlying anemia in acute rejection.
Organism:
Homo sapiens
Type:
Expression profiling by array, log2 ratio, 4 individual sets
Platform:
GPL3306
Series:
GSE3976
4 Samples
Download data
DataSet
Accession:
GDS1700
ID:
1700
2.

Molecular profiling of anemia in acute renal allograft rejection

(Submitter supplied) Compromised renal function after renal allograft transplantation often results in anemia in the recipient. Molecular mechanisms leading to anemia during acute rejection are not fully understood; inadequate erythropoietin production and iron deficiency have been reported to be the main contributors. To increase our understanding of the molecular events underlying anemia in acute rejection, we analyzed the gene expression profiles of peripheral blood lymphocytes (PBL) from four pediatric renal allograft recipients with acute rejection and concurrent anemia, using DNA microarrays containing 9000 human cDNA clones (representing 7469 unique genes). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1700
Platform:
GPL3306
4 Samples
Download data
Series
Accession:
GSE3976
ID:
200003976
3.

Expression data from skin, dermis, and epidermis of epithelial activated beta-catenin mutant mouse embryo

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE10733
ID:
200010733
4.

Expression data from epidermis of epithelial activated beta-catenin mutant mouse embryo

(Submitter supplied) β-catenin signaling is required for hair follicle development, but it is unknown whether it is sufficient to activate expression of hair follicle genes in embryonic skin. To address this we profiled gene expression in epidermis from E15.5 KRT14-Cre Ctnnb1(Ex3)fl/+ embryos carrying an activating mutation in epithelial beta-catenin, and control littermate embryos. Keywords: Genetic modification
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL, CHP, EXP, XLS
Series
Accession:
GSE10728
ID:
200010728
5.

Expression data from dermis of epithelial activated beta-catenin mutant mouse embryo

(Submitter supplied) β-catenin signaling is required for hair follicle development, but it is unknown whether it is sufficient to activate expression of hair follicle genes in embryonic skin. To address this we profiled gene expression in dermis from E15.5 KRT14-Cre Ctnnb1(Ex3)fl/+ embryos carrying an activating mutation in epithelial beta-catenin, and control littermate embryos. Keywords: Genetic modification
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL, CHP, EXP, XLS
Series
Accession:
GSE10727
ID:
200010727
6.

Expression data from skin of epithelial activated beta-catenin mutant mouse embryo

(Submitter supplied) β-catenin signaling is required for hair follicle development, but it is unknown whether it is sufficient to activate expression of hair follicle genes in embryonic skin. To address this we profiled gene expression in skin dissected from E14.5 KRT14-Cre Ctnnb1(Ex3)fl/+ embryos carrying an activating mutation in epithelial beta-catenin, and control littermate embryos. Keywords: Genetic modification
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL, CHP, EXP, XLS
Series
Accession:
GSE10726
ID:
200010726
7.

Molecular heterogeneity in acute renal allograft rejection

(Submitter supplied) The data set contains 67 array (lymphochip cDNA array), published in N Engl J Med 2003 Jul 10;349(2):125-38. PMID: 12853585. TITLE: Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. BACKGROUND: The causes and clinical course of acute rejection vary, and it is not possible to predict graft outcome reliably on the basis of available clinical, pathological, and genetic markers. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL271 GPL272
67 Samples
Download data
Series
Accession:
GSE343
ID:
200000343
8.

Kidney Transplant Rejection and Tissue Injury by Gene Profiling of Biopsies and Peripheral Blood Lymphocytes

(Submitter supplied) We used DNA microarrays (HG-U95Av2 GeneChips) to determine gene expression profiles for kidney biopsies and peripheral blood lymphocytes (PBLs) in transplant patients. Sample classes include kidney biopsies and PBLs from patients with 1) healthy normal donor kidneys, 2) well-functioning transplants with no clinical evidence of rejection, 3) kidneys undergoing acute rejection, and 4) transplants with renal dysfunction without rejection. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS724
Platform:
GPL8300
62 Samples
Download data: CEL, EXP
Series
Accession:
GSE1563
ID:
200001563
9.
Full record GDS724

Kidney transplant rejection expression profiling

Analysis of kidney transplant rejection by expression profiling of kidney biopsies and peripheral blood lymphocytes from patients. Results identify expression profiles unique to rejection, dysfunction without rejection, and well-functioning transplants.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 individual, 2 tissue sets
Platform:
GPL8300
Series:
GSE1563
62 Samples
Download data: CEL, EXP
10.

Increased metallothionein expression reflects steroid resistance in renal allograft recipients.

(Submitter supplied) Steroid-refractory acute rejection is a risk factor for inferior renal allograft outcome. We aimed to gain insight into the mechanisms underlying steroid resistance by identifying novel molecular markers of steroid-refractory acute rejection. Eighty-three kidney transplant recipients (1995-2005), who were treated with methylprednisolone during a first acute rejection episode, were included in this study. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6883
40 Samples
Download data: TXT
Series
Accession:
GSE47097
ID:
200047097
11.

A peripheral blood gene expression signature diagnoses subclinical acute rejection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL11154 GPL5175
153 Samples
Download data: CEL, TXT
Series
Accession:
GSE120398
ID:
200120398
12.

A peripheral blood gene expression signature diagnoses subclinical acute rejection [validation]

(Submitter supplied) Histological features of acute rejection can be detected in surveillance biopsies despite stable graft function and can negatively impact graft outcomes. However, routine surveillance biopsies for detection of subclinical rejection are not generally performed due to potential risks and costs associated with repeated biopsies. Noninvasive biomarkers are required to facilitate early detection of acute rejection and borderline changes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
65 Samples
Download data: CEL
Series
Accession:
GSE120397
ID:
200120397
13.

A peripheral blood gene expression signature diagnoses subclinical acute rejection [discovery]

(Submitter supplied) Histological features of acute rejection can be detected in surveillance biopsies despite stable graft function and can negatively impact graft outcomes. However, routine surveillance biopsies for detection of subclinical rejection are not generally performed due to potential risks and costs associated with repeated biopsies. Noninvasive biomarkers are required to facilitate early detection of acute rejection and borderline changes. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
88 Samples
Download data: TXT
14.

Molecular characterization of chronic antibody mediated rejection in kidney transplantation (mRNA CD4)

(Submitter supplied) Chronic antibody-mediated rejection (CAMR) represents the main cause of kidney graft loss, but its pathogenesis is unclear. In order to uncover the molecular mechanisms underlying this condition, we characterized the molecular signature of circulating peripheral blood mononuclear cells and, separately, of CD4+ T lymphocytes isolated from CAMR patients compared to kidney transplant recipients with normal graft function and histology. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
10 Samples
Download data: TXT
Series
Accession:
GSE64261
ID:
200064261
15.

Molecular characterization of chronic antibody mediated rejection in kidney transplantation (microRNA)

(Submitter supplied) Chronic antibody-mediated rejection (CAMR) represents the main cause of kidney graft loss, but its pathogenesis is unclear. In order to uncover the molecular mechanisms underlying this condition, we characterized the molecular signature of circulating peripheral blood mononuclear cells and, separately, of CD4+ T lymphocytes isolated from CAMR patients compared to kidney transplant recipients with normal graft function and histology. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL16770
9 Samples
Download data: TXT
Series
Accession:
GSE51676
ID:
200051676
16.

Molecular characterization of chronic antibody mediated rejection in kidney transplantation (mRNA)

(Submitter supplied) Chronic antibody-mediated rejection (CAMR) represents the main cause of kidney graft loss, but its pathogenesis is unclear. In order to uncover the molecular mechanisms underlying this condition, we characterized the molecular signature of circulating peripheral blood mononuclear cells and, separately, of CD4+ T lymphocytes isolated from CAMR patients compared to kidney transplant recipients with normal graft function and histology. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
18 Samples
Download data: TXT
Series
Accession:
GSE51675
ID:
200051675
17.

Expression profile of syngeneic (sTX) and allogeneic kidney (aTX) transplantation compared to control (ctr) kidneys

(Submitter supplied) Microarray analyses provide a powerful approach to identify gene expression alterations following kidney transplantation. However, the heterogeneity of human kidney transplant specimens and the variation in sample preparation precludes conclusions regarding the underlying mechanisms of the observed alterations. We used a well defined experimental rat kidney transplantation model with consistent transplant and sample preparation procedures to analyze genome wide changes in gene expression after syngeneic (sTX) and allogeneic transplantation (aTX) four days after transplantation. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
15 Samples
Download data: CEL, EXP
Series
Accession:
GSE6497
ID:
200006497
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