Similar studies for GEO DataSets (Select 1745) - GEO DataSets

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Items: 2

Select item 17451.

Succinate semialdehyde dehydrogenase deficiency effect on the brain

Analysis of brain hippocampi, cerebella, and cortices of succinate semialdehyde dehydrogenase (SSADH)-deficient mutants at 3 weeks of age, when fatal seizures occur. Results indicate that SSADH deficiency results in the dysregulation of genes involved in myelin structure and compaction.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation, 3 tissue sets

Platform:: GPL81
Series:: GSE2866
18 Samples

Download data: CEL

DataSet

Accession:: GDS1745

ID:: 1745

Select item 2000028662.

Donarum-3R01NS040270-03S1

(Submitter supplied) Succinate semialdehyde dehydrogenase (SSADH) deficiency is a rare autosomal recessive disorder effecting approximately 350 people around the world. Patients suffering from SSADH deficiency experience language acquisition failure, memory deficiencies, autism, increased aggressive behaviors, and seizures. There is a chemical buildup of both gamma-aminobutyric acid (GABA) and gamma-hydroxybutyric acid (GHB) in the neurological system of these patients. more...