GEO DataSets

Comparison of healing diaphyseal femoral fractures treated with intramedullary nail fixation or with internal plate fixation. Expression profiles examined at various time points up to 6 weeks post-treatment. Results provide insight into the effect of fracture fixation technique on fracture repair.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 protocol, 3 shock, 7 time sets

Platform:

GPL85

Series:

GSE1685

19 Samples

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(Submitter supplied) This is a study of femoral fracture healing in female rats 16 weeks old at fracture to compare intramedullary nailing, screw and plate fixation, and sham surgery. The sham surgery group received a surgical exposure of the femur, but no fracture, no plate, and no nail. Samples were collected at 1 day, 3 days, 1 week, 2 weeks, 4 weeks, and 6 weeks after surgery. Each sample is a pool of RNA from three rats from the same surgery group at the same time point after fracture. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1853

Platform:

GPL85

19 Samples

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(Submitter supplied) A study of rat femoral fracture healing in young (6 weeks old at fracture), adult (26 weeks old at fracture), and old (52 weeks old at fracture) rats. Samples were collected at time of surgery (intact controls) and at 3 days, 1 week, 2 weeks, 4 weeks, and 6 weeks after fracture. Samples were the mid third of the femoral length including the external callus, cortical bone and marrow elements. Fracture was stabilized with an intramedullary rod prior to fracture with a Bonnarens and Einhorn device. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1995

Platform:

GPL85

18 Samples

Download data: CEL

(Submitter supplied) mRNA gene expression was measured in intact female Sprague-Dawley rats at 6 (young), 26 (adult) and 52 (older) weeks of age at the time of fracture. Samples were collected at 0, 0.4, 1, 2, 4, and 6 weeks after fracture. RNA from two rats were pooled for each Affymetrix Rat U34A array. Mid-shaft, simple, transverse left femoral fractures were induced after retrograde intramedullary rod fixation with a Bonnarens and Einhorn device. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS509

Platform:

GPL85

54 Samples

Download data: CEL

(Submitter supplied) Study of rat femur fracture healing in young (6 weeks old), adult (26 weeks old), and older (52 weeks old) rats with samples collected at 0 time (no fracture) and at 0.4, 1, 2, 4, and 6 weeks after fracture. RNA from two rats were pooled for each array. Keywords = rat, femur, fracture, age, time Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

18 Samples

Download data: CEL

(Submitter supplied) mRNA gene expression was measured in rats at 6 (young), 26 (adult) and 52 (older) weeks of age at the time of fracture. Samples were collected at 0, 0.4, 1, 2, 4, and 6 weeks after fracture. RNA from two rats were pooled for each Affymetrix Rat U34A array. Keywords = rat Keywords = fracture Keywords = age Keywords = time Keywords = femur Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

18 Samples

Download data: CEL

Analysis of healing femurs of 6, 26, and 52-week-old Sprague-Dawley females at various time points up to 6 weeks after fracture. 6, 26, and 52-week-old animals regain normal skeletal biomechanics 4 weeks, 10 weeks, and 6 months after fracture, respectively.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 age, 2 protocol, 6 time sets

Platform:

GPL85

Series:

GSE1371

18 Samples

Download data: CEL

Temporal analysis of gene expression following femoral fracture. Female Sprague-Dawleys at 6 (young), 26 (adult) and 52 (older) weeks of age at time of fracture. Samples analyzed at 0, 3 days, 1, 2, 4, and 6 weeks after fracture.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 age, 6 time sets

Platform:

GPL85

Series:

GSE594

36 Samples

Download data: CEL

(Submitter supplied) Phosphate is essential for healthy bone growth and plays an essential role in fracture repair. Although phosphate deficiency has been shown to impair fracture healing, the mechanisms involved in impaired healing are unknown. More recently, studies have shown that the effect of phosphate deficiency on the repair process varied based on the genetic strain of mice, which is not characterized. We used data from microarrays to (1) determine the effects of phosphate restriction on the biologic functions identified from the gene expression in fracture calluses; and (2) examine whether there are genetic differences within the primary biologic functions.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19485

239 Samples

Download data: CEL