GEO DataSets

Analysis of renal mesangial MES-13 cells treated with high glucose or glucosamine. Mesangial cells play an important role in the development of diabetic glomerulosclerosis and renal failure. Glucosamine and high glucose mimic the hyperglycemic and hemodynamic insults of diabetic kidney disease.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL1261

Series:

GSE2557

6 Samples

Download data

(Submitter supplied) The renal mesangial cells play an important role in the development of diabetic glomerulosclerosis and renal failure. We have previously demonstrated some of the effects of high glucose are mediated via the hexosamine biosynthesis pathway (HBP) in which fructose-6-phosphate is converted to glucosamine-6-phosphate by the rate-limiting enzyme glutamine:fructose-6-phosphate amidotransferase (GFAT). Using Affymetrix murine expression U430 2.0 chips, we examined the global effects of high glucose (HG) and glucosamine (GlcN) on the transcriptomes of a mouse mesangial cell line (MES-13). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1891

Platform:

GPL1261

6 Samples

Download data

(Submitter supplied) HMCs were treated with CsA (4.2 µM) for 0 12 and 48 hours. To exmaine global gene changes in the renal mesangium following CsA treatment in order to identify novel contributors to CsA-induced renal dysfunction Microarray analysis was used to identify novel mechanisms of CsA nephrotoxicity in the golmerulus

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

6 Samples

Download data: CEL

(Submitter supplied) Cells were grown on collagen coated insert for 21 days under 25mM (high glucose) or 5mM (control) glucose conditions. We investigated relevant target genes that could be regulated by high glucose levels in CaCo-2 cells. We intended to find candidate genes that may play a role for intestinal glucose absorption. Fund Source: The Scientific and Technological Research Council of Turkey Project ID: 214Z217 (T B TAK/ PN:214Z217)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

6 Samples

Download data: TXT