GEO DataSets

Discovery of genes with restricted expression patterns in wing disc and potential roles in wing disc development. Wing imaginal discs dissected to generate body wall and wing/hinge fragments. Three biological replicates of each examined.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL72

Series:

GSE93

6 Samples

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(Submitter supplied) Wing imaginal discs were dissected to generate body wall and wing/hinge fragments. Targets from three biological replicates of each were generated and the expression profiles were determined using Affymetrix Drosophila Genechip 1 arrays. Comparisons between the sample groups allow the identification of genes with localized expression patterns. Keywords = Drosophila, wing disc, spatially restricted transcripts Keywords: repeat sample

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS192

Platform:

GPL72

6 Samples

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(Submitter supplied) Signaling between cells in the Anterior (A) and Posterior (P) compartments directs Drosophila wing disc development and is dependent on expression of the homeodomain transcription factor Engrailed (En) in P cells. Downstream of en, posteriorly expressed Hedgehog (Hh) protein signals across the A/P border to establish a developmental organizer that directs pattern formation and growth throughout the wing primordium. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL2581

12 Samples

Download data: TXT

(Submitter supplied) Hox genes regionalize the animal body axis by modifying complex morphogenetic and differentiation processes during development. The transformation of wings into halteres by the Hox gene Ultrabithorax (Ubx) in Drosophila melanogaster presents an excellent model system to study the transcriptional networks that control such complex developmental programmes. We have employed an inducible misexpression system to switch on Ubx in the wing epithelium at successive larval, prepupal and pupal stages, and have used microarray expression profiling to identify the primary transcriptional responses to Ubx. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

48 Samples

Download data: CEL

(Submitter supplied) The identity of every segment in the fruitfly Drosophila melanogaster is determined by the action of one or more homeotic selector genes. These genes encode proteins containing DNA-binding domains and function by regulating downstream target genes. The structure and function of homeotic genes are highly conserved across a wide range of animals including human. Although much information is available on the molecular and biochemical nature of homeotic genes, comparatively little is known regarding the mechanism/s that are used to generate segmental diversity. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platforms:

GPL1239 GPL1240

16 Samples

Download data: TIFF, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Drosophila melanogaster

Type:

Genome binding/occupancy profiling by genome tiling array; Expression profiling by array

Platforms:

GPL14121 GPL15057

12 Samples

Download data: PAIR, SGR, TXT

(Submitter supplied) The outcome of Notch proliferation on proliferation depends on the context. In Drosophila wing imaginal discs Notch activation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand te underlying mechanisms we have used genomic strategies to identify the Notch-Su(H) target genes during wing discs hyperplasis. these data are the results from expression profiling the RNAs from hyperplastic wing discs overexpressing Nicd.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL14121

4 Samples

Download data: TXT

(Submitter supplied) The outcome of Notch activation of proliferation depends on cellular context. In Drosophila wing discs Notch pathway overactivation results in hyperplasia. To understand the mechanisms we have used genomic strategies to indetify the Notch-S(H) target genes directly regulated in wing disc hyperplasia. These data are the results from expression profiling the RNAs from hyperplastic wing discs overexpressing Su(H).

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL14121

3 Samples

Download data: TXT

(Submitter supplied) The outcome of Notch activation on proliferation depends on cellular context. In Drosophila wing discs Notch activation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms we have used genomic strategies to identify the Notch-Su(H) target genes directly activated during wing disc hyperplasia. These data are the results from ChIP-Chip experiments to identify genomic regions occupied by Su(H) in hyperplastic Nicd-expressing Drosophila wing discs.

Organism:

Drosophila melanogaster

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL15057

2 Samples

Download data: PAIR, SGR, TXT

(Submitter supplied) The outcome of Notch activation on proliferation depends on cellular context. In Drosophila wing discs Notch activation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms we have used genomic strategies to identify the Notch-Su(H) target genes directly activated during wing disc hyperplasia. These data are the results from ChIP-Chip experiments to identify genomic regions occupied by Su(H) in hyperplastic Su(H)-expressing Drosophila wing discs.

Organism:

Drosophila melanogaster

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL15057

3 Samples

Download data: PAIR, SGR, TXT

(Submitter supplied) Research on the ability of certain organisms to reconstruct missing structures of their bodies is still in its infancy, despite numerous efforts performed in multiple species. Using expression profile analyses on different timepoints that cover wound healing and regeneration processes (0, 24 and 72 hours post injury), we studied the regenerative behaviour of fragmented wing imaginal discs of D. melanogaster implanted into adult flies. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL3797

12 Samples

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(Submitter supplied) We used here a combination of lineage tracing, FACS and genome-wide RNAseq to identify two key changes that accompany hinge-to-pouch fate change: (1) repression of hinge determinants and (2) upregulation of ribosome biogenesis.

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19132

12 Samples

Download data: TXT

(Submitter supplied) The Drosophila wing disc has been a fundamental model system for the discovery of key signaling pathways and for our understanding of developmental processes. However, a complete map of gene expression in this tissue is lacking. To obtain a complete gene expression atlas in the wing disc, we employed single-cell sequencing (scRNA-seq) and developed a new method for analyzing scRNA-seq data based on gene expression correlations rather than cell mappings. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17275 GPL22106

7 Samples

Download data: CSV, TSV, TXT

(Submitter supplied) Profiled chromatin accessibility and gene expression in the wing imaginal discs of Drosophila melanogaster, in wild type and nub[1] animals. We demonstrate using RNA-seq that expression of both nub and pdm2 paralogs are reduced in the nub[1] condition, and that this allele contains a previously unannotated deletion within the intergenic region between of nub and pdm2 using ATAC-seq that corresponds to a wing enhancer element.

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL19132

14 Samples

Download data: BIGWIG, CSV

(Submitter supplied) Transcription profiling of third instar male larvae of two different heteroallelic combinations of ssdp hypomorphic alleles, ssdp[neo48]/ssdp]BG1663] and ssdp[31]/ssdp[BG1663] were compared to each of the corresponding single heterozygotes

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL20

22 Samples

Download data: TXT

(Submitter supplied) We used microarrays to detail the global gene expression changes following RNAi knock-down of dTip60 in Drosophila SL2 cells

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

10 Samples

Download data: CEL, CHP

(Submitter supplied) Background: Despite the prevalence and biological relevance of both signalling pathways and alternative pre-mRNA splicing, our knowledge of how intracellular signalling impacts on alternative splicing regulation remains fragmentary. We report a genome-wide analysis of changes in alternative splicing using splicing-sensitive microarrays, induced by activation of two distinct signalling pathways, insulin and wingless, in Drosophila cells in culture. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL7508

6 Samples

Download data: TXT

(Submitter supplied) We measured gene expression across the whole genome in a panel of lines selected for a wing shape trait (angular offset). The lines were created in separate experiments, originating from two widely separated populations, and including multiple replicates of one population, but all were created using the same selection regime and trait. Here we evaluate the data with two objectives: 1) to identify candidate wing shape genes for future testing and validation, and 2) to assess variation among lines in the outcome of identical selection regimes We used microarrays to detail the global programme of gene expression underlying the phenotypic differences among strains selected for wing shape angular offset. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

36 Samples

Download data: CEL

(Submitter supplied) We profiled the transcriptome of Drosophila melanogaster embryos in ttk2D50 embryos or after over-expression using btl-GAL4; UAS-ttk, respectively. We further isolated cells that express btl-enh-RFPmoe (Cabernard and Affolter 2005) and FACS sorting, and profiled their transcriptomes in the same genetic backgrounds.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL13770

19 Samples

Download data: CEL

(Submitter supplied) Cell migration contributes to normal development and homeostasis as well as to pathological processes such as inflammation and tumor metastasis. Previous genetic screens have revealed a few major signaling pathways that govern follicle cell migrations in the Drosophila ovary, several of which elicit transcriptional responses. However few downstream targets of the critical transcriptional regulators, such as the C/EBP homolog SLBO, have been identified. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS1877

Platform:

GPL72

12 Samples

Download data: CEL