GEO DataSets

(Submitter supplied) A whole-genome microarray containing 97.4 % of the annotated genes of L. acidophilus was employed to compare genome-wide patterns of transcription at varying pHs between the wild type parent and a histidine protein kinase mutant Keywords: ordered

Organism:

Lactobacillus acidophilus

Type:

Expression profiling by array

Platform:

GPL1401

6 Samples

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(Submitter supplied) Lactic acid bacteria have been used as starter strains in the production of fermented dairy products for centuries. Lactobacillus acidophilus is a widely recognized probiotic bacteria commonly added to yogurt and used in dietary supplements. In this study, a whole genome microarray was employed to monitor gene expression of L. acidophilus cells propagated in 11% skim milk (SM) during early, mid and late logarithmic phase, and stationary phase. more...

Organism:

Lactobacillus acidophilus NCFM; Lactobacillus acidophilus

Type:

Expression profiling by array

Platform:

GPL1401

6 Samples

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(Submitter supplied) Lactobacillus acidophilus NCFM is an industrially important strain used extensively as a probiotic culture. Tolerance of the presence of bile is an attribute important to microbial survival in the intestinal tract. A whole-genome microarray was employed to examine the effects of bile on the global transcriptional profile of this strain, with the intention of elucidating genes contributing to bile tolerance. more...

Organism:

Lactobacillus acidophilus; Lactobacillus acidophilus NCFM

Type:

Expression profiling by array

Platform:

GPL1401

2 Samples

Download data: TXT

(Submitter supplied) A L. acidophilus NCFM mutant (NCK1909) carrying an in-frame deletion within the upp gene (LBA0770) was constructed as a background host for a newly developed upp-based counterselectable gene replacement system for L. acidophilus. Since the NCK1909 mutant serves both as the host for genetic exchange and the reference strain for subsequent phenotypic studies of deletion mutants that will be generated from the counterselective gene replacement system, comparative gene expression study was performed to ensure the genotype of NCK1909 is representative of the NCFM parent strain. more...

Organism:

Lactobacillus acidophilus NCFM

Type:

Expression profiling by array

Platform:

GPL7426

4 Samples

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(Submitter supplied) L. acidophilus cells, transferred at least five times in modified MRS medium (Barrangou et al, 2003) containing the carbohydrate of interest, were grown to an OD600 of 0.6, harvested and processed for microarray experiments (Azcarate-Peril et al, 2005). Keywords: other

Organism:

Lactobacillus acidophilus

Type:

Expression profiling by array

Platform:

GPL1401

28 Samples

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(Submitter supplied) Dendritic cells (DC) play a pivotal regulatory role in activation of the innate as well as the adaptive part of the immune system by responding to environmental microorganisms. We have previously shown that some lactobacilli strains induce a strong production of the pro-inflammatory and Th1 polarizing cytokine IL-12 in DC. Contrary, bifidobacteria do not induce IL-12, but are able to inhibit the IL-12 production induced by lactobacilli. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3813

Platform:

GPL1261

12 Samples

Download data: CEL

Analysis of dendritic cells (DC) co-stimulated with B. bifidum and L. acidophilus. DCs are involved in the initiation of both innate and adaptive immunity by responding to environmental microorganisms. Results provide insight into the immune response in DCs elicited by this co-stimulation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 agent sets

Platform:

GPL1261

Series:

GSE20302

12 Samples

Download data: CEL

(Submitter supplied) Most members of the phylum Firmicutes harbor a two-component system, LiaSR, which is involved in the response to cell envelope stress elicited most notably by inhibitors of the lipid II cycle. In all LiaSR systems studied in detail LiaSR-mediated signal transduction was shown to be negatively controlled by a membrane protein, LiaF, encoded upstream of liaSR. In this study we have analysed the LiaSR homolog of Listeria monocytogenes (LiaSRLm). more...

Organism:

Listeria monocytogenes EGD-e; Listeria monocytogenes

Type:

Expression profiling by array

Platform:

GPL10909

11 Samples

Download data: TXT

(Submitter supplied) Lactobacilli are probiotics that, among other health promoting effects, have been ascribed immunostimulating and virus preventive properties. Certain lactobacilli species have been shown to possess strong IL-12 inducing properties. As IL-12 production depends on the up-regulation of type I interferons, we hypothesized that the strong IL-12 inducing capacity of L. acidophilus NCFM in murine bone marrow derived DC is caused by an up-regulation of IFN-β, which subsequently stimulates the induction of IL-12 and the dsRNA binding toll like receptor (TLR)-3. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

16 Samples

Download data: CEL

(Submitter supplied) The Gram-positive bacterium Listeria monocytogenes is widely distributed in the environment and capable of causing food-borne infections in susceptible individuals. In this study, we investigated the cell envelope stress response in L. monocytogenes. Whole-genome transcriptional profiling was performed to investigate the response upon exposure to the cell wall antibiotic cefuroxime. Differential expression (≥ 2-fold difference) of 558 genes was observed, corresponding to 20% of the L. more...

Organism:

Listeria monocytogenes EGD-e; Listeria monocytogenes

Type:

Expression profiling by array

Platform:

GPL14687

16 Samples

Download data: TXT

(Submitter supplied) The autoinducer-2 (AI-2) group of signalling molecules represent a new type of cell-cell communication since they are produced by many phylogenetic groups of bacteria as the by product of a metabolic transformation carried out by the luxS enzyme. To separate the metabolic function of the luxS enzyme from the signalling role of AI-2, we carried out a global transcriptome analysis of a luxS null mutant of Streptococcus mutans UA159, an important cariogenic bacterium and crucial component of the dental plaque biofilm community. more...

Organism:

Streptococcus mutans; Streptococcus mutans UA159

Type:

Expression profiling by array

Platform:

GPL4031

44 Samples

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(Submitter supplied) Helicobacter pylori causes chronic gastritis and avoids elimination by the immune system of the infected host. The commensal bacterium Lactobacillus acidophilus has been reported to exert beneficial effects as a supplement during H. pylori eradication therapy. In the present study, we applied whole genome microarray analysis to compare the immune response induced in murine bone marrow derived macrophages (BMDM) stimulated with L. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

12 Samples

Download data: TXT