Similar studies for GEO DataSets (Select 200006817) - GEO DataSets

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Items: 16

Select item 2000068171.

Downregulation of Human Melanotransferrin on SK-Mel-28 Cell Line

(Submitter supplied) Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin. MTf is expressed at very low levels in normal tissues and in high amounts in melanoma cells. The over-expression of MTf in tumor cells was hypothesized to assist rapidly proliferating neoplastic cells with their increased Fe requirements. However, our recent characterization of the MTf knockout (MTf -/-) mouse demonstrated that MTf did not have an essential role in Fe metabolism. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
3 Samples

Download data: CEL

Series

Accession:: GSE6817

ID:: 200006817

Select item 2000068332.

Hyperexpression and Downregulation of Melanotransferrin on Various Cell Lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL570 GPL1261
9 Samples

Download data: CEL

Series

Accession:: GSE6833

ID:: 200006833

Select item 2000068163.

Hyperexpression of Human Melanotransferrin on SK-N-MC Cell Line

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
2 Samples

Download data: CEL

Series

Accession:: GSE6816

ID:: 200006816

Select item 2000068154.

Hyperexpression of Mouse Melanotransferrin on LMTK Cell Line

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE6815

ID:: 200006815

Select item 2000045235.

Expression Studies of Melanotransferrin in Mouse Brain

(Submitter supplied) Melanotransferrin (MTf) or melanoma tumor antigen p97 is an iron (Fe)-binding transferrin homolog expressed highly on melanomas and at lower levels on normal tissues. It has been suggested that MTf is involved in a variety of processes such as Fe metabolism and cellular differentiation. Considering the crucial role of Fe in many metabolic pathways e.g., DNA synthesis, it is important to understand the function of MTf. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1964
Platform:: GPL1261
6 Samples

Download data

Series

Accession:: GSE4523

ID:: 200004523

Select item 19646.

Melanotransferrin effect on brain

Analysis of brain from melanotransferrin (MTf) knockout mutants. MTf or melanoma tumor antigen p97 is a membrane bound iron binding transferrin homolog highly expressed in melanomas and at lower levels in normal tissues. Results provide insight into the function of MTf.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE4523
6 Samples

Download data

DataSet

Accession:: GDS1964

ID:: 1964

Select item 2000075497.

Nm23-H1 suppresses tumor cell motility by downregulating the LPA receptor

(Submitter supplied) Exogenous overexpression of the metastasis suppressor gene Nm23-H1 reduces the metastatic potential of multiple types of cancer cells. In addition, Nm23-H1 expression suppresses in vitro tumor cell motility and invasion, important correlates of metastasis. The molecular mechanism by which Nm23-H1 suppresses metastasis, motility and invasion has yet to be defined. However, mutational analysis of Nm23-H1 has revealed that substitution mutant P96S and S120G are unable to inhibit cell motility. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4608
11 Samples

Download data: TXT

Series

Accession:: GSE7549

ID:: 200007549

Select item 2000105258.

Gene expression profile of Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP)

(Submitter supplied) Gene expression profile of Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) reveals murine targets for preclinical development of human prostate cancer therapy In this study, we have generated an open source TRAMP microarray dataset to identify differentially expressed genes from human prostate cancer that have concordant expression in TRAMP tumors, and thereby represent lead targets for preclinical therapy development. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
18 Samples

Download data: CEL

Series

Accession:: GSE10525

ID:: 200010525

Select item 2000107489.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3643
Platform:: GPL1355
24 Samples

Download data: CEL

Series

Accession:: GSE10748

ID:: 200010748

Select item 364310.

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 6 dose sets

Platform:: GPL1355
Series:: GSE10748
24 Samples

Download data: CEL

DataSet

Accession:: GDS3643

ID:: 3643

Select item 20002278711.

Affymetrix HG-U133A 2.0 Expression data

(Submitter supplied) Expression .CEL files from Affymetrix HG-U133A 2.0 arrays using DNA from 14 human cell lines derived from metastasized melanoma

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
14 Samples

Download data: CEL

Series

Accession:: GSE22787

ID:: 200022787

Select item 20000271512.

SK-MEL-2 cells treated with Ad-E2F-1, Ad-E2F-1 plus doxorubicn or Ad-LacZ plus doxorubicin

(Submitter supplied) SK-MEL-2 cells treated with Ad-E2F-1 (MOI 2), Ad-E2F-1 (MOI 2)plus doxorubicin 0.1uM, or Ad-LacZ (MOI 2) plus doxorubicin 0.1uM Keywords: ordered

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2244
Platform:: GPL96
6 Samples

Download data

Series

Accession:: GSE2715

ID:: 200002715

Select item 224413.

Melanoma cell line response to E2F-1 overexpression and doxorubicin treatment

Analysis of E2F-1 overexpressing SK-MEL-2 melanoma cells treated with the anti-cancer drug doxorubicin (dox). Results provide insight into the molecular mechanisms underlying the synergistic effect on melanoma cell apoptosis observed when E2F-1 overexpression is combined with dox treatment

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 agent sets

Platform:: GPL96
Series:: GSE2715
6 Samples

Download data

DataSet

Accession:: GDS2244

ID:: 2244

Select item 20001055214.

Genome wide expression analysis in AtT-20 cells following Dnmt1 knockdown

(Submitter supplied) Efficient and sustained knockdown of DNMT1 transcript and protein was achieved using a consecutive transfection protocol in the mouse pituitary adenoma cell line, AtT-20. Genome wide microarray analysis identified 91 transcripts that were significantly differentially expressed relative to cells treated with a non-targeting control. Keywords: Differential expression

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE10552

ID:: 200010552

Select item 20000980715.

Expression data from RNAi SNCA treated human neuroblastoma cell line

(Submitter supplied) The pre-synaptic protein α-synuclein is a key player in the pathogenesis of Parkinson's disease. Together with accumulation and missfolding of α-synuclein protofibrils serve as seed structures for the aggregation of numerous proteins in the cytoplasm of neuronal cells, the so-called Lewy bodies. Furthermore, missense mutations in the SNCA gene and gene multiplications lead to autosomal dominant forms of familiar PD. more...