GEO DataSets

(Submitter supplied) We developed spotted oligonucleotide arrays of the S. pyogenes SF370 (an M1 serotype) genome and compared the transcriptomes of streptococci that adhere to Detroit 562 human pharyngeal cells to non-adherent (“associated”) streptococci within the same experiment. We replicated experiments independently and used dye-swaps to incorporate biological and technical variation, biological replicate experiments. more...

Organism:

Streptococcus pyogenes

Type:

Expression profiling by array

Platform:

GPL5122

8 Samples

Download data: TXT

(Submitter supplied) Relatively little is understood about the dynamics of global host–pathogen transcriptome changes that occur during bacterial infection of mucosal surfaces. To test the hypothesis that group A Streptococcus (GAS) infection of the oropharynx provokes a host transcriptome response, we performed genome-wide transcriptome analysis using a nonhuman primate model of experimental pharyngitis. We also identified host and pathogen biological processes and individual host and pathogen gene pairs with correlated patterns of expression, suggesting interaction. more...

Organism:

Homo sapiens; Macaca fascicularis

Type:

Expression profiling by array

Platform:

GPL96

360 Samples

Download data: CEL, CHP

(Submitter supplied) Identification of the genetic events that contribute to host-pathogen interactions is important for understanding the natural history of infectious diseases and developing therapeutics. Transcriptome studies conducted on pathogens have been central to this goal in recent years. However, most of these investigations have focused on specific end points or disease phases, rather than analysis of the entire time course of infection. more...

Organism:

Borreliella burgdorferi; Chlamydia trachomatis; Staphylococcus aureus; Yersinia pestis; Macaca fascicularis; Coxiella burnetii; Streptococcus pyogenes

Type:

Expression profiling by array

Platform:

GPL2129

259 Samples

Download data: CEL, EXP, TXT

(Submitter supplied) Infection of the human host by Streptococcus pneumoniae begins with colonization of the nasopharynx, which is mediated by adherence of bacteria to respiratory epithelium. Several studies have indicated an important role for the pneumococcal capsule in this process. Here, we used microarrays to characterize the in vitro transcriptional response of human nasopharyngeal epithelial Detroit 562 cells to adherence of serotype 2-encapsulated strain D39, serotype 19F-encapsulated strain G54, serotype 4-encapsulated strain TIGR4, and their nonencapsulated derivatives (Δcps). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3041

Platform:

GPL570

32 Samples

Download data: CEL, EXP

Analysis of pharyngeal epithelial cells exposed to various encapsulated strains of Streptococcus pneumoniae. Nasopharynx colonization by S. pneumoniae is mediated by adherence to the respiratory epithelium. Results provide insight into the capsule-dependent host response to pneumococcal adherence.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 agent, 3 cell type, 3 dose, 2 infection sets

Platform:

GPL570

Series:

GSE8527

32 Samples

Download data: CEL, EXP

(Submitter supplied) We investigated the covS-regulation of S. pyogenes in a hypervirulent M23 strain using RNA-sequencing. The differential gene expression comparison between the covS- mutant and isogenic wild type covS+ identified altered expression of 349 (18%) genes, including a broad spectrum of virulence genes and diverse metabolic genes. The data showed that the strain achieved hypervirulence by enhancing the expression of genes responsible for invasiveness and antiphagocytosis (i.e., hasABC), by abrogating the expression of toxic genes (i.e., speB), and by compromising gene products with dispensable functions (i.e., sfb1). more...

Organism:

Streptococcus pyogenes

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19982

8 Samples

Download data: XLS

(Submitter supplied) We compared the gene expression patterns of macrophages infected with S. oralis wild type and SpxB KO, a strain that does not produce H2O2.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL21810

8 Samples

Download data: TXT

(Submitter supplied) The expression levels of developing rat molar transcriptome were measured. 5 samples each from embryonic day 15.5, and 17.5 of rat developing molar tooth.

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20084

15 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Rattus norvegicus; Myodes glareolus

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

5 related Platforms

109 Samples

Download data: CEL

(Submitter supplied) Single cell RNAseq of E14.5 mouse molar Analysis of gene expression in single cell of mouse E14.5 molar

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

4 Samples

Download data: TXT

(Submitter supplied) The expression levels of developing mouse molar transcriptome were measured. 7 samples each from embryonic day 13.5, 14.5 and 16.5 of mouse developing molar tooth.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

28 Samples

Download data: TXT

(Submitter supplied) The expression levels of developing mouse molar transcriptome were measured. 5 samples of both E13.5 and E14.5 of mouse developing molar tooth.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL27901

10 Samples

Download data: CEL