GEO DataSets

(Submitter supplied) We are investigating the molecular development of squamous cell lung carcinoma based upon analysis of global gene expression profiles representing progressive stages of cancer development, consisting of precancerous, carcinoma-in-situ, and invasive cancer. Keywords: global gene expression analysis, lung cancer development

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL4

13 Samples

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(Submitter supplied) 24 SAGE libraries comprising of 8 current smokers, 12 former smokers and 4 never smokers. Keywords: SAGE, gene expression, current, former, never, smokers

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL4

24 Samples

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(Submitter supplied) A description of the transcriptome of human bronchial epithelium should provide a basis for studying lung diseases including cancer. We demonstrate here that minute epithelial specimens obtained by bronchial brushings afford reliable profiling by serial analysis of gene expression (SAGE) leading to lung gene discovery. We have deduced global gene expression profiles of bronchial epithelium and lung parenchyma, based upon a vast data set of nearly two million sequence tags from 21 SAGE libraries generated from individuals with a history of smoking. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL4

21 Samples

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(Submitter supplied) 19 bronchial epithelial SAGE libraries were constructed and analyzed in this study. Discussed in the study: IDENTIFICATION OF NOVEL LUNG GENES IN BRONCHIAL EPITHELIUM BY SERIAL ANALYSIS OF GENE EXPRESSION Kim M. Lonergan1, Raj Chari1, Ronald J. deLeeuw1, Ashleen Shadeo1, Bryan Chi1, Ming-Sound Tsao2, Steven Jones3, Marco Marra3, Victor Ling1, Raymond Ng1,4, Calum MacAulay5, Stephen Lam5 and Wan L. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL4

19 Samples

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(Submitter supplied) Detection, treatment, and prediction of outcome for lung cancer patients increasingly depend on a molecular understanding of tumor development and sensitivity of lung cancer to therapeutic drugs. The application of genomic technologies, such as microarray, is widely used to monitor global gene expression and has built up invaluable information and knowledge, which is essential to the discovery of new insights into the mechanisms common to cancer cells, resulting in the identification of unique, identifiable signatures and specific characteristics. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

66 Samples

Download data: CEL, EXP

(Submitter supplied) Cigarette smoking is the main risk factor for the development of squamous cell lung carcinoma (SCC). However, the smoking-related molecular changes in SCC have not been studied. We wanted to identify genes in both histologically normal bronchial epithelium and SCC samples that are differentially expressed between current and ex-smokers. In addition, to analyze the levels of the smoking-related genes identified in normal bronchial epithelium with the levels in SCC. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1708

62 Samples

Download data: PDF, TXT

(Submitter supplied) unmatched samples

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL2845

4 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL2845

105 Samples

Download data: TXT

(Submitter supplied) Gene expression differences between between matched tumor and normal samples were analyzed using paired t-test. Keywords: disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL2845

90 Samples

Download data: TXT

(Submitter supplied) Gene expression differences between the tumor subtypes AC and SCC were analyzed using t-test. Keywords: disease subtype analysis

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL2845

56 Samples

Download data: TXT

(Submitter supplied) Non-small cell lung cancer (NSCLC) can be classified into the major subtypes adenocarcinoma (AC) and squamous cell carcinoma (SCC) subtypes. Although explicit molecular, histological and clinical characteristics have been reported for both subtypes, no specific therapy exists so far. However, the characterization of suitable molecular targets holds great promises to develop novel therapies in NSCLC. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3627

Platform:

GPL570

58 Samples

Download data: CEL

Comparison of two non-small cell lung cancer histological subtypes: adenocarcinomas (AC) and squamous cell carcinomas (SCC). Results provide insight into the molecular differences between AC and SCC.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL570

Series:

GSE10245

58 Samples

Download data: CEL

(Submitter supplied) Understanding the molecular events in non-small cell lung cancer (NSCLC) is essential to improve early diagnosis and treatment for this disease. We examined the effect of chromosomal copy number changes on gene expression in resected NSCLC patients. We identified a deletion on 14q32.2-33 as a common alteration in NSCLC (44%), which significantly influenced gene expression for HSP90AA1, residing on 14q32. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL2827

32 Samples

Download data: XLS

(Submitter supplied) To analyze the effect of different aliments, male OF1 mice were fed ad libitum with a custom-made diet containing 33% maize derived from three cultivars containing comparable nutritional values for multiple generations. To evaluate possible effects on the gene expression in the small intestine, the jejunum of nine randomly chosen males of the F3 was sampled at the age of 7 weeks. Note that the lack of information on the time of sampling or its randomization between the experimental groups limited the value of the internal microarray data set for the context originally addressed (diet).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2995

9 Samples

Download data: TXT

(Submitter supplied) Background: Lung-resident immune cells around local environment of non-small cell lung cancers implicate the balance of pro- and anti-tumor immunity; however the transcriptomic profiles of these cells remain poorly understood. Methods: Transcriptomic microarray study of lung-resident immune cells, harvested by bronchoalveolar lavage, was performed in the discovery group and the findings were validated in published microarray datasets and in an independent group by RT-qPCR

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

19 Samples

Download data: CEL

(Submitter supplied) To identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer, tongue squamous cell carcinoma, hypopharyngeal squamous cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20844

16 Samples

Download data: TXT

(Submitter supplied) To identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer, bladder cancer, prostate cancer, renal cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20844

32 Samples

Download data: TXT, XLSX

(Submitter supplied) To assess the dynamic changes in the immune contexture during early lung carcinogenesis, we performed immune profiling using the nCounter PanCancer Immune Profiling Panel on resected lung ADCs and their precursors .

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL19965

85 Samples

Download data: TXT, XLSX

(Submitter supplied) This study was designed to understand the transcriptomic composition and the biological functions of cancer stem cells isolated from non-small cell lung cancer line (NSCLC) Putative lung cancer stem cells were isolated from cancer cell lines based on expression of known stem cell surface markers: CD166, CD44 and EpCAM using the Fluorescence Activated Cell Sorter (FACS).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

15 Samples

Download data: CEL, CHP

(Submitter supplied) Lung squamous cell carcinoma (SCC) is thought to arise from premalignant lesions in the airway epithelium, therefore studying these lesions is critical for understanding lung carcinogenesis. We performed RNA sequencing on laser-microdissected representative cell populations along the SCC pathological continuum of patient-matched normal basal cells, premalignant lesions, and tumor cells. We discovered transcriptomic changes and identified genomic pathways altered with initiation and progression of SCC within individual patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL11154 GPL10999

24 Samples

Download data: TXT