Similar studies for GEO DataSets (Select 200009547) - GEO DataSets

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Items: 17

Select item 2000095471.

p53 status and BaP or BPDE gene expression response

(Submitter supplied) Human colon carcinoma cells (HCT116) differing in p53 status were exposed to benzo(a)pyrene (BaP) (2.5 and 5 uM for up to 48 h) or anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide (BPDE)(0.5 and 1 uM for up to 24 h), and their gene expression responses compared by cDNA microarray technology. Keywords: BaP or BPDE exposure

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4348
47 Samples

Download data: GPR

Series

Accession:: GSE9547

ID:: 200009547

Select item 2000058942.

benzo(a)pyrene_MCF7_HepG2

(Submitter supplied) MCF-7 and HepG2 cells were exposed to a range of concentrations of benzo(a)pyrene or benzo(e)pyrene (0-5 uM) for up to 48 h and gene expression analysis performed. Keywords: dose response

Organism:: Homo sapiens

Type:: Expression profiling by array

4 related Platforms
96 Samples

Download data

Series

Accession:: GSE5894

ID:: 200005894

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000109793.

A study of temporal transcriptional changes induced by a low concentration BPDE in cultured human cells

(Submitter supplied) The environmental carcinogen, (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), causes bulky-adduct DNA damages, triggers certain signaling pathways, and elicits gene expression changes. Here, we focused on the temporal gene expression changes induced by a low concentration (0.05 µM) BPDE in human amnion epithelial FL cells. Differential gene expression profiles at 1, 10 and 22 h post BPDE treatment were obtained using Affymetrix HG-U133 Plus 2.0 oligonucleotide microarrays. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
18 Samples

Download data: CEL, EXP

Series

Accession:: GSE10979

ID:: 200010979

Select item 2000247514.

Pulmonary gene and microRNA expression changes in mice exposed to benzo(a)pyrene by oral gavage

(Submitter supplied) Polycyclic aromatic hydrocarbons (PAHs) are widely distributed, carcinogenic environmental contaminants produced as a consequence of the incomplete combustion of fossil fuels. Benzo[a]pyrene (BaP) is a very extensively studied prototypical PAH. We recently reported a complete lack of change in microRNA (miRNA) expression in adult mouse liver following oral gavage with BaP despite a robust transcriptome response. more...

Organism:: Mus musculus

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL4134 GPL8824
45 Samples

Download data: TXT

Series

Accession:: GSE24751

ID:: 200024751

Select item 2000269175.

Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene

(Submitter supplied) BACKGROUND: Benzo[a]pyrene (BaP) is a widespread environmental genotoxic carcinogen that damages DNA by forming adducts. This damage along with activation of the aryl hydrocarbon receptor (AHR) induces complex transcriptional responses in cells. To investigate whether human cells are more susceptible to BaP in a particular phase of the cell cycle, synchronised breast carcinoma MCF-7 cells were exposed to BaP. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
24 Samples

Download data: TXT

Series

Accession:: GSE26917

ID:: 200026917

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000103596.

p53 status and AAI gene expression response

(Submitter supplied) Human colon carcinoma cells (HCT116) differing in TP53 status were exposed to aristolochic acid I (AAI) (50 and 100 uM for up to 48 h), and their gene expression responses compared by cDNA microarray technology. Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4348
36 Samples

Download data: GPR

Series

Accession:: GSE10359

ID:: 200010359

Select item 2000195107.

Transcriptional response of normal human lung WI-38 fibroblasts to benzo[a]pyrene diol epoxide: a dose-response study

(Submitter supplied) Cellular responses to carcinogens are typically studied in transformed cell lines, which do not reflect the physiological status of normal tissues. To address this question, we have characterized the transcriptional program and cellular responses of normal human lung WI-38 fibroblasts upon exposure to the ultimate carcinogen benzo[a]pyrene diol epoxide (BPDE). Exposure to BPDE induces a strong inflammatory response in WI-38 primary fibroblasts. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3706
Platform:: GPL570
14 Samples

Download data: CEL

Series

Accession:: GSE19510

ID:: 200019510

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 37068.

Benzo[a]pyrene diol epoxide effect on lung WI-38 fibroblasts: dose-response

Analysis of normal lung WI-38 fibroblasts exposed to various concentrations of the carcinogen benzo[a]pyrene diol epoxide (BPDE). BPDE is a metabolite of benzo[a]pyrene, a component of cigarette smoke. Results provide insight into the molecular response of normal lung fibroblasts to BPDE.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 4 dose sets

Platform:: GPL570
Series:: GSE19510
14 Samples

Download data: CEL

DataSet

Accession:: GDS3706

ID:: 3706

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000434389.

Sub-chronic forestomach transcriptional response in adult male MutaTMMouse following oral exposure to benzo(a)pyrene

(Submitter supplied) Benzo(a)pyrene is a well-established human carcinogen in humans and rodents. In the present study, we sought to determine the dose- and time-dependent changes in gene expression upon oral exposure to benzo(a)pyrene. Adult male MutaTMMouse were exposed to three doses of benzo(a)pyrene or vehicle control (olive oil) for 28 days and sacrificed three days after the final exposure.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
17 Samples

Download data: TXT

Series

Accession:: GSE43438

ID:: 200043438

Select item 20003624410.

Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL9052 GPL13695
16 Samples

Download data: CEL, TXT

Series

Accession:: GSE36244

ID:: 200036244

Select item 20003624311.

Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (Affymetrix)

(Submitter supplied) Whole-genome transcriptome measurements are pivotal for characterizing carcinogenic mechanisms of chemicals and predicting toxic classes, such as genotoxicity, from in vitro and in vivo assays. DNA microarrays have evolved as the gold standard for this purpose. In recent years deep sequencing technologies have been developed that hold the promise of measuring the transcriptome with RNA-seq in a more accurate and unbiased manner than microarrays. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13695
8 Samples

Download data: CEL, TXT

Series

Accession:: GSE36243

ID:: 200036243

Select item 20003624212.

Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (RNA-Seq)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9052
8 Samples

Download data: TXT

Series

Accession:: GSE36242

ID:: 200036242

Select item 20000672213.

Agilent _CRUK_platform_comparison

(Submitter supplied) HepG2 cells were exposed to similar concentrations of BaP in two different laboratories (2.5 uM at Institute of Cancer Research and 3 uM at Maastricht University)for 6 and 24 h. Gene expression was analysed by Agilent oligonucleotide microarrays and Cancer Research UK (CR-UK) cDNA microarrays. An inter-laboratory and inter-platform comparison were performed on the data. Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL4348 GPL887
32 Samples

Download data: GPR, TXT

Series

Accession:: GSE6722

ID:: 200006722

Select item 20000307214.

Ecdysone- and stress-induced expression profile in Kc167 cells

(Submitter supplied) Kc167 cells were mock-treated/treated with combinations of steroid hormone ecdysone and gamma-irradiation, and harvested. The expression profiles were determined using Affymetrix Drosophila Genechip 1 arrays. Comparisons between the sample groups allow the identification of genes with ecdysone- and/or radiation-responsive expression patterns. Keywords: response to hormone, stress response

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS2355
Platform:: GPL72
4 Samples

Download data: CEL, EXP

Series

Accession:: GSE3072

ID:: 200003072

Select item 20000278015.

Radiation-induced Dmp53-dependent expression profile

(Submitter supplied) Embryos were collected, aged, mock-treated/treated with 40Gy gamma radiation, and allowed to recover for 1.5 hours. Targets from 3 sets of wild type (yw, w1118) and 2 sets of mutant (Dmp53NS) biological replicates were generated and the expression profiles were determined using Affymetrix Drosophila Genechip 1 arrays. Comparisons between the sample groups allow the identification of genes with radiation-responsive and Dmp53-dependent expression patterns. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS2665
Platform:: GPL72
10 Samples

Download data: CEL, EXP

Series

Accession:: GSE2780

ID:: 200002780

Select item 266516.

p53 mutant embryo response to radiation

Analysis of p53 mutant embryos exposed to gamma radiation. Within 90 minutes of radiation exposure, apoptosis is observed in embryonic and post-embryonic tissues of wild type but not p53 mutants. Results provide insight into the molecular basis of this p53-dependent apoptogenic response.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array, count, 2 agent, 3 strain sets

Platform:: GPL72
Series:: GSE2780
10 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS2665

ID:: 2665

Select item 235517.

Ecdysone treatment and gamma-irradiation effect

Analysis of Kc167 cells following gamma-irradiation, ecdysone treatment, or both. Pretreatment of Kc167 cells with ecdysone increases the sensitivity of these cells to gamma-irradiation.