Similar studies for GEO DataSets (Select 200010002) - GEO DataSets

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Items: 17

Select item 2000100021.

Identification of Erythroid-Enriched Gene Expression in the Mouse Embryonic Yolk Sac using Microdissected Cells

(Submitter supplied) Primitive erythropoiesis in the mouse yolk sac is followed by definitive erythropoiesis resulting in adult erythrocytes. In comparison to definitive erythropoiesis little is known about the genes that control the embryonic erythroid program. The purpose of this study was to generate a profile of mouse embryonic yolk sac erythroid cells and identify novel regulatory genes differentially expressed in erythroid compared to non-erythroid (epithelial cells). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3405
Platform:: GPL8321
8 Samples

Download data: CEL

Series

Accession:: GSE10002

ID:: 200010002

Select item 34052.

Embryonic erythroid precursors

Analysis of primitive erythroid precursors and epithelial cells isolated from frozen sections of the embryonic day 9.5 yolk sac. Results provide insight into the molecular mechanisms underlying embryonic erythropoiesis.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 cell type sets

Platform:: GPL8321
Series:: GSE10002
8 Samples

Download data: CEL

DataSet

Accession:: GDS3405

ID:: 3405

Select item 2000103483.

Identification of differentially expressed genes in runx1-/- primitive erythroid

(Submitter supplied) Targeted disruption of the Runx1/ AML1 gene in mice has demonstrated that it is required for the emergence of definitive hematopoietic cells, but that it is not essential for the formation of primitive erythrocytes. These findings led to the conclusion that Runx1 is a stage-specific transcription factor acting only during definitive hematopoiesis. However, the zebrafish and Xenopus homologues of Runx1 have been shown to play roles in primitive hematopoiesis, suggesting that mouse Runx1 might also be involved in the development of primitive lineages. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL922
1 Sample

Download data: TXT

Series

Accession:: GSE10348

ID:: 200010348

Select item 2001712894.

A Positive Regulatory Feedback Loop Between EKLF/ KLF1 and TAL1/SCL Sustaining the Erythropoiesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:: GPL13412 GPL1261
10 Samples

Download data: CEL, CHP, PAIR

Series

Accession:: GSE171289

ID:: 200171289

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001712015.

ChIP-Chip data from WT E14.5 fetal liver

(Submitter supplied) The erythroid Krüppel-like factor EKLF/KLF1 is a hematopoietic transcription factor binding to CACCC DNA motif and participating in the regulation of erythroid differentiation. With combined use of microarray-based gene expression profiling and promoter-based ChIP-chip assay of E14.5 fetal liver cells from wild type (WT) and EKLF-knockout (Eklf-/-) mouse embryos, we have identified the pathways and direct target genes activated or repressed by EKLF. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL13412
2 Samples

Download data: PAIR

Series

Accession:: GSE171201

ID:: 200171201

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001712006.

Microarray expression level comparison between WT and KO fetal liver cells

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE171200

ID:: 200171200

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001037897.

A novel role for Lyl1 in primitive erythropoiesis

(Submitter supplied) Stem Cell Leukemia (Scl or Tal1) and Lymphoblastic Leukemia 1 (Lyl1) are highly related members of the basic helix-loop-helix (bHLH) family of transcription factors that are co- expressed in hematopoietic stem cells and the erythro-megakaryocytic lineages. Previous studies suggest that Scl is essential for hematopoietic development including primitive erythropoiesis. However, analysis of single-cell RNA-sequencing data of early embryos showed that primitive erythroid cells express both Scl and Lyl1. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
12 Samples

Download data: TXT

Series

Accession:: GSE103789

ID:: 200103789

PubMed Similar studies SRA Run Selector

Select item 2000430448.

The role of Ldb1 in hemangioblast development: genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL1261 GPL13112
16 Samples

Download data: CEL

Series

Accession:: GSE43044

ID:: 200043044

Select item 2000430429.

(Submitter supplied) The first site exhibiting hematopoietic activity in mammalian development is the yolk sac blood island, which originates from the hemangioblast. Here we performed differentiation assays, as well as genome-wide molecular and functional studies in BL-CFCs to gain insight into the function of the essential Ldb1 factor in early primitive hematopoietic development. We show that the previously reported lack of yolk sac hematopoiesis and vascular development in Ldb1-/- mouse result from a decreased number of hemangioblasts and a block in their ability to differentiate into erythroid and endothelial progenitor cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE43042

ID:: 200043042

Select item 20004304110.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
10 Samples

Download data: TXT

Series

Accession:: GSE43041

ID:: 200043041

PubMed Similar studies SRA Run Selector

Select item 20003661811.

Mechanisms of terminal erythroid differentiation defect in EKLF-deficient mice

(Submitter supplied) EKLF is a Krüppel-like transcription factor identified as a transcriptional activator and chromatin modifier in erythroid cells. EKLF-deficient (Eklf -/-) mice die at day 14.5 of gestation from severe anemia. In this study, we demonstrate that early progenitor cells fail to undergo terminal erythroid differention in Eklf -/- embryos. To discover potential EKLF target genes responsible for the failure of erythropoiesis, transcriptional profiling was performed with RNA from wild type and Eklf -/- early erythroid progenitor cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE36618

ID:: 200036618

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001887312.

High throughput sequencing of RNAPII-Ser5P ChIP DNA

(Submitter supplied) The discovery of interchromosomal interactions in higher eukaryotes points to a functional interplay between genome architecture and gene expression, challenging the view of transcription as a one-dimensional process. However, the extent of interchromosomal interactions and the underlying mechanisms are unknown. Here we present the first genome-wide analysis of transcriptional interactions using the mouse globin genes in erythroid tissues. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9522
1 Sample

Download data: FNA, TXT

Series

Accession:: GSE18873

ID:: 200018873

PubMed Full text in PMC Similar studies

Select item 20003299113.

Dynamic transcriptomes during human erythroid differentiation and development

(Submitter supplied) To explore the mechanisms controlling erythroid differentiation and development in human, we analyzed the genome-wide transcription dynamics that occurs during the differentiation of HESCs into the erythroid lineage and development of embryonic to adult erythropoiesis using high throughput sequencing technology. Undifferentiated HESCs as well as erythroid cells at three developmental stages-ESER (embryonic stage), FLER (fetal stage) and PBER (adult stage)-were analyzed. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9442
4 Samples

Download data: WIG

Series

Accession:: GSE32991

ID:: 200032991

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20001240714.

Gene expression in erythroid cell differentiation

(Submitter supplied) Human mononuclear cells were cultured in 2 phases. In the 1st phase the culture medium contained cyclosporine A the 2nd phase contained SCF and erythropoietin. Cells were collected at 3 stages of differentiation; on day 6, 10, 12 and represented early erythroblasts, medium stage and normoblasts. Keywords: time course

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE12407

ID:: 200012407

Select item 20003673115.

Gene expression profiling in Vav-Etv2 KSL and Granulocyte hematopoietic cells

(Submitter supplied) Etv2 transgene was expressed from ROSA26 locus by removing floxed STOP cassette by Vav Cre transgene. KSL or Mac1+/Gr1+ cells were sorted from control or Vav-Etv2 bone marrow and compared for gene expression in duplicate. This study will reveal the effect of Etv2 transgene in adult hematopoietic cells. The effect of Etv2 overexpression in relevant mouse tissue will be important to understand its effect in comparison with in ES cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
8 Samples

Download data: TXT

Series

Accession:: GSE36731

ID:: 200036731

Select item 20003651616.

Gene expression profiling in Tie-2-Etv2 endothelial and/or hematopoietic precursors

(Submitter supplied) Etv2 transgene was expressed from ROSA26 locus by removing floxed STOP cassette by Tie-2 Cre transgene. VE-Cad+/CD45= or VE-Cad+/CD45+ cells were sorted from control or tie-2-Etv2 E11.5 embryos (YS;yolk sac and Emb;embryo proper)and compared for gene expression in duplicate.