GEO DataSets

(Submitter supplied) Drosophila melanogaster undergoes a complete metamorphosis, during which time the larval male and female forms transition into sexually dimorphic, reproductive adult forms. To understand this complex morphogenetic process at a molecular-genetic level, we performed whole genome microarray analyses. In somatic tissues at 48 hour After Puparium Formation (APF), 173 sex-biased transcripts that likely function downstream of the doublesex (dsx) branch of the sex determination hierarchy were identified. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL6799

28 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL6799

88 Samples

Download data: GPR

(Submitter supplied) Drosophila melanogaster undergoes a complete metamorphosis, during which time the larval male and female forms transition into sexually dimorphic, reproductive adult forms. To understand this complex morphogenetic process at a molecular-genetic level, we performed whole genome microarray analyses. Genes were identified that were expressed during metamorphosis in both somatic and germline tissues of males and females. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL6799

60 Samples

Download data: GPR

(Submitter supplied) The Drosophila sex determination hierarchy consists of a splicing cascade with sex-specific transcription directing somatic sexual dimorphism. Our understanding of this pathway, and many others, is incomplete. Here we pioneer an approach to expand our knowledge of gene regulatory networks (GRNs) by leveraging natural genetic variation. This approach is generalizable to any natural population, including humans. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11203

9 Samples

Download data: CSV

(Submitter supplied) Drosophila melanogaster adult males perform an elaborate courtship ritual to entice females to mate. fruitless (fru), a gene that is one of the key regulators of male courtship behavior, encodes multiple male-specific isoforms (FruM). These isoforms vary in their carboxy-terminal zinc finger domains, which are predicted to facilitate DNA binding. By over-expressing individual FruM isoforms in fru-expressing neurons in either males or females and assaying the global transcriptional response by RNA-sequencing, we show that three FruM isoforms have different regulatory activities that depend on the sex of the fly. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11203

39 Samples

Download data: CSV

(Submitter supplied) Abstract: Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germline tissue were used to further analyze tissue-specific gene expression programs. These studies define major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

4 related Platforms

170 Samples

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(Submitter supplied) Eyes absent mutant adult flies collected 0-24 hours after eclosion, with N=2 biological collections for males and females each. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Keywords: Logical Set

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL2839

4 Samples

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(Submitter supplied) Four separate biological collections of unfertilized eggs laid by wildtype females mated with sterile males, eggs dechorionated and snap-forzen in liquid nitrogen 0-1 hour after egg lay. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Keywords: Logical Set

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL2839

4 Samples

Download data

(Submitter supplied) Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germline tissue were used to further analyze tissue-specific gene expression programs. These studies define major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes A development or differentiation experiment design type assays events associated with development or differentiation or moving through a life cycle. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platforms:

GPL2837 GPL2840 GPL2838

162 Samples

Download data

(Submitter supplied) Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germline tissue were used to further analyze tissue-specific gene expression programs. These studies define major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL218

159 Samples

Download data

(Submitter supplied) The process of metamorphosis relies on choreography of temporal and spatial cues that mediate, in which inappropriate activation of many of these genes results in growth defects, developmental delay and death. Using RNA interference, we have unraveled an essential role for the insect specific dopamine 1(D1)-like receptor Dop1R2 at the late larval/prepupal stage. We used microarrays to evaluate differentially expressed genes during the early/pale pupal stage and identified up-regulation of families of functionally related genes, including ecdysone induced genes, stress and defense/immune response genes, and those that underlie tissue morphogenesis.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL72

4 Samples

Download data: CEL, CHP

(Submitter supplied) The Drosophila sex determination hierarchy controls all aspects of somatic sexual differentiation, including sex-specific differences in adult morphology and behavior. To gain insight into the molecular-genetic specification of reproductive behaviors and physiology, we identified genes expressed in the adult head and central nervous system that are regulated downstream of sex-specific transcription factors encoded by doublesex (dsx) and fruitless (fru). more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL5983

42 Samples

Download data: GPR

(Submitter supplied) Eye-stalks of some flies exhibit extreme sexual dimorphism, but little is known about the genetic mechanisms producing variation in these ornamental traits. Therefore, we constructed an EST database of genes expressed in the developing eye-antennal imaginal disc of the highly dimorphic species, Teleopsis dalmanni, and used this set of genes to construct high density oligoarrays and compare patterns of gene expression between lines of flies selected for divergent eyespan. more...

Organism:

Teleopsis dalmanni

Type:

Expression profiling by array

Platform:

GPL8358

8 Samples

Download data: GPR

(Submitter supplied) Each 44K array contains 9 features for each of ~3600 genes that have been identified in an EST study of eye-antennal discs from late instar larvae or pupae of a diopsid stalk-eyed fly. cDNA clusters were included that had 1) significant homology to known genes in Drosophila or Anopheles, 2) an ORF larger than 300 bp (labeled ORF-) or 3) more than four associated cDNA clones (labeled X-). Three 60 bp oligonucleotide probes were designed for each gene based on the consensus sequence with the highest Blast hit or largest ORF within each cluster. more...

Organism:

Teleopsis dalmanni

1 Series

8 Samples

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(Submitter supplied) In order to test the hypothesis that adult hybrid misexpression results from the cascading effect of earlier-expressed developmentally important improperly regulated genes, as well as address whether Von Baer’s 3rd law (suggesting that earlier stages of development should be more similar between species than later stages) holds at the level of gene expression, we conducted whole-transcriptome Drosophila melanogaster cDNA microarray-based expression profiling of males of D. more...

Organism:

Drosophila melanogaster; Drosophila sechellia; Drosophila simulans; Drosophila sechellia x Drosophila simulans

Type:

Expression profiling by array

Dataset:

GDS3835

Platform:

GPL3598

48 Samples

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Analysis of males of 3 species (melanogaster, sechellia, simulans) and D. sechellia x D. simulans F1 hybrids during 4 developmental stages. Results within and between pure species and hybrids provide insight into both the evolution of gene regulation in the context of development and speciation.

Organism:

Drosophila melanogaster; Drosophila sechellia; Drosophila simulans; Drosophila sechellia x Drosophila simulans

Type:

Expression profiling by array, log2 ratio, 4 development stage, 4 species sets

Platform:

GPL3598

Series:

GSE17535

48 Samples

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(Submitter supplied) This study identifies those genes that are dependent on EcR for their proper regulation at the onset of metamorphosis in Drosophila melanogaster. Keywords: Nuclear receptor gene regulation

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS2675

Platform:

GPL72

18 Samples

Download data: CEL

(Submitter supplied) To identify 20E-regulated genes, wandering third instar larvae were dissected and their organs were cultured in the presence of either no hormone, 20E alone, cycloheximide alone, or 20E plus cycloheximide for six hours. Keywords: Hormone response

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS2674

Platform:

GPL72

12 Samples

Download data: CEL

(Submitter supplied) This study identifies genes that alter their expression in synchrony with the late third instar and prepupal pulses of 20E. Keywords: time course

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS2673

Platform:

GPL72

27 Samples

Download data: CEL

Analysis of ecdysone receptor (EcR) depleted animals 4 hours before to 4 hours after the start of pupariation. EcR is part of receptor complex for 20-hydroxyecdysone (20E), a hormone that triggers developmental transitions in insects. Results provide insight into the mechanisms regulated by 20E.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, count, 2 development stage, 2 protocol, 3 time sets

Platform:

GPL72

Series:

GSE3069

18 Samples

Download data: CEL