Similar studies for GEO DataSets (Select 200011913) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2000119131.

Illumina expression data from LNCaP cells overexpressing either SOX4 or GFP

(Submitter supplied) SOX4 is a critical developmental transcription factor in vertebrates and is required for precise differentiation and proliferation in multiple tissues. In addition, SOX4 is overexpressed in many human malignancies, but the precise role of SOX4 in cancer progression is not well understood. Here we have performed an expression profiling experiment of LNCaP cells either overexpressing SOX4 or GFP to identify SOX4 target genes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6102
12 Samples

Download data: TXT

Series

Accession:: GSE11913

ID:: 200011913

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000119152.

SOX4 effect on LNCaP prostate cancer cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

5 related Platforms
34 Samples

Download data: CEL, TXT

Series

Accession:: GSE11915

ID:: 200011915

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000119143.

Expression data from LNCaP cells transfected with SOX4 cDNA, SOX4 siRNA or GFP cDNA

(Submitter supplied) SOX4 is a critical developmental transcription factor in vertebrates and is required for precise differentiation and proliferation in multiple tissues. In addition, SOX4 is overexpressed in many human malignancies, but the precise role of SOX4 in cancer progression is not well understood. Here we have either eliminated SOX4 using siRNA or overexpressed a SOX4 cDNA and compared the gene expression patterns against control GFP transfections to identify SOX4 target genes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL96 GPL97
12 Samples

Download data: CEL

Series

Accession:: GSE11914

ID:: 200011914

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000118744.

Chromatin Immunoprecipitation microarray data from antiHA IP in stable LNCaP cells expressing either YFP or HA-SOX4/YFP

(Submitter supplied) SOX4 is a critical developmental transcription factor in vertebrates and is required for precise differentiation and proliferation in multiple tissues. In addition, SOX4 is overexpressed in many human malignancies, but the precise role of SOX4 in cancer progression is not well understood. Here we have identified the direct transcriptional targets of SOX4 using a genome-wide localization ChIP-chip analysis. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array

Platforms:: GPL6325 GPL6326
10 Samples

Download data: TXT

Series

Accession:: GSE11874

ID:: 200011874

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001256435.

The effects of SOX4 on the global epigenetic landscape in Mammary Epithelial Cells

(Submitter supplied) By chromatine-immunoprecipitating (ChIP) using the mammary epithelial cell line HMLE with a Doxycyclin-inducible overexpression of SOX4 we determined various histone modifications and presence of the POL2 polymerase in presence and absence of overexpressed SOX4.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
9 Samples

Download data: BW

Series

Accession:: GSE125643

ID:: 200125643

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001256426.

RNA-sequencing of human mammary epithelial cells (HMLEs) engineered to express either ER or ER-SOX4 with and without 4-OHT to induce nuclear translocation

(Submitter supplied) Through RNA-sequencing we analysed the differentially expressed genes upon inducible activation of SOX4.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: DIFF

Series

Accession:: GSE125642

ID:: 200125642

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001047617.

The interplay between SOX4 and SMAD3 in the context of breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. The experiments are described in 2 papers: PMID 30137431 and PMID 30507376

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
50 Samples

Download data: BIGWIG, BW

Series

Accession:: GSE104761

ID:: 200104761

PubMed Full text in PMC Similar studies

Select item 2001047608.

SMAD3 and SOX4 binding profiling in human breast cell lines

(Submitter supplied) In order to identify genes co-bound by SOX4 and SMAD3 in the context of breast cancer, different breast cell lines (HMLEs, MDA-MB-231 or HCC-1954) were used. Due to low endogenous expression levels for SOX4 in HMLEs in untreated conditions, doxycycline-dependent SOX4 overexpression was obtained by transducing HMLE cells with pIINDUCER21-SOX4 vector..Cells were plated and SOX4 and SMAD3 chromatine-immunoprecipitation was performed in untreated conditions, TGF-beta (2.5ng/ml), doxycycline (0.5ug/ml) or both as indicated. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
25 Samples

Download data: BIGWIG, BW

Series

Accession:: GSE104760

ID:: 200104760

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001047599.

RNA-sequencing of human mammary epithelial cells (HMLEs) transduced in vitro with a shRNA against SOX4 or a scrambled shRNA in untreated and TGF-β-treated (16 hours) conditions

(Submitter supplied) In order to identify SOX4- and TGF-beta dependent genes, human mammary epithelial cells (HMLEs) were transduced with shRNA scrambled (control) or shRNA targeting SOX4 (TRCN0000018213, Sigma Aldrich, St. Louis, MS) and selected with puromycin for at least 2 weeks. SOX4 knockdown was confirmed by qRTPCR and western blotting. Cells were plated in 6 well plates and either left untreated or treated with TGF-beta (2.5ng/ml) for 16 hours in biological duplicate (different passages). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: TXT

Series

Accession:: GSE104759

ID:: 200104759

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20009925610.

Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis

(Submitter supplied) The expression of the transcription factor SOX4 is increased in many human cancers, however, the pro-oncogenic capacity of SOX4 can vary greatly depending on the tumor-type. Both the contextual nature and the mechanisms underlying the pro-oncogenic SOX4 response remain unexplored. Here, we demonstrate that in mammary tumorigenesis, the SOX4 transcriptional network is dictated by the epigenome and is enriched for pro-angiogenic processes. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
11 Samples

Download data: TXT

Series

Accession:: GSE99256

ID:: 200099256

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003161211.

Identification of SOX4 novel transcriptional targets.

(Submitter supplied) The SOX4 gene belongs to a family of transcription factors and we previously unveiled SOX4 gene amplification and over-expression in a subset of lung cancers, indicating it may constitute a driver oncogene. Here, we searched for SOX4 transcriptional targets and investigate their involvement in lung development and carcinogenesis. We abrogated SOX4 expression in the NIH-H522 lung cancer cell line, carrying SOX4 amplification and over-expression, using an inducible short-hairpin system. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
4 Samples

Download data: JPG, TXT

Series

Accession:: GSE31612

ID:: 200031612

Select item 20011857212.

Expression data for T24 bladder cancer cell line - scrambled, SOX4-KD and SOX4 overexpression

(Submitter supplied) We knocked down SOX4 in T24 cell and created 3 cell lines: T24-scrambled, T24-SOX4-knockdown and T24-SOX4-rescue and compared gene expression changes SOX4 is a developmental transcription factor that is overexpressed in as many as 23% of bladder cancer patients, but the role of SOX4 in bladder cancer tumorigenesis is not well understood. Given SOX4’s many roles in embryonic development and context-dependent regulation of gene expression, we sought to understand SOX4’s contribution to bladder cancer and to elucidate SOX4 regulated genes that might contribute to tumorigenesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23126
10 Samples

Download data: CEL

Series

Accession:: GSE118572

ID:: 200118572

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001407913.

Gene expression analysis & Comparative genomic hybridization from Lung cancer Cell lines

(Submitter supplied) Gene expression and Comparative genomic hybridization (CGH) microarrays performed in a set of 8 Lung cancer Cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by array

Platform:: GPL1998
16 Samples

Download data: GPR

Series

Accession:: GSE14079

ID:: 200014079

Select item 20000622214.

Genome-wide analysis of gene expression patterns in human liver cancers

(Submitter supplied) To investigate the mechanisms of liver cancer progression and metastasis, we did expression profiling of human liver cancer and benign tissues. Keywords: gene expression array-based (RNA / in situ oligonucleotide)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
13 Samples

Download data: CEL

Series

Accession:: GSE6222

ID:: 200006222

Select item 20005130115.

Genes regulated by SOX4 in glioblastoma cell line

(Submitter supplied) Overexpression of SOX4 in LN229 glioblastoma cells prevents their cell cycle We used microarrays to detail the global programme of gene expression in SOX4 overexpression LN229 cells compared with mock control LN229 cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15207
2 Samples

Download data: CEL

Series

Accession:: GSE51301

ID:: 200051301

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013832816.

SOX4-mediated repression of specific tRNAs inhibits proliferation of human glioblastoma cells

(Submitter supplied) Genomic targeted genes of SOX4 in U251 cell line

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE138328

ID:: 200138328

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005006717.

Unraveling the Sox4-orchestrated pro-B cell differentiation program: Intricate roles of the RAG and CK1e genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL6887 GPL13112
14 Samples

Download data: TXT

Series

Accession:: GSE50067

ID:: 200050067

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005006618.

Unraveling the Sox4-orchestrated pro-B cell differentiation program: Intricate roles of the RAG and CK1ε genes (ChIP-Seq)

(Submitter supplied) Commitment of hematopoietic stem cells to B lineage precursors and development of B lineage precursors into mature B cells is attained through the coordinated function of multiple signaling networks, which are in turn controlled through stringent functioning of stage-specific transcription factors. Here, we describe the essential role of Sox4, an HMG (high mobility group)-box-containing transactivator, in B cell development. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: TXT

Series

Accession:: GSE50066

ID:: 200050066

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005006519.

Unraveling the Sox4-orchestrated pro-B cell differentiation program: Intricate roles of the RAG and CK1ε genes (RNA array)

(Submitter supplied) One of the main objective of this study is to identify Sox4 controlled gene networks and their roles in progenitor B cells. Commitment of hematopoietic stem cells to B lineage precursors and development of B lineage precursors into mature B cells is attained through the coordinated function of multiple signaling networks, which are in turn controlled through stringent functioning of stage-specific transcription factors. more...