Similar studies for GEO DataSets (Select 200013319) - GEO DataSets

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Items: 20

Select item 2000133191.

Comparison of Human and Rat Uterine Leiomyoma: Identification of a Dysregulated mTOR Pathway

(Submitter supplied) Uterine leiomyomata, or fibroids, are benign tumors of the uterine myometrium that significantly affect up to 30% of reproductive-age women. Despite being the primary cause of hysterectomy in the United States, accounting for up to 200,000 procedures annually, the etiology of leiomyoma remains largely unknown. Due to the lack of an effective medicinal therapy for these tumors, this disease continues to have a tremendous negative impact on women’s health. more...

Organism:: Homo sapiens; Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL570 GPL1355
106 Samples

Download data: CEL

Series

Accession:: GSE13319

ID:: 200013319

Select item 2000005932.

Uterine Fibroid and Normal Myometrial Expression Profiles- U133 Arrays

(Submitter supplied) Our study seeks to identify genes differentially expressed between uterine leiomyomas and normal myometrial tissue. This series consists of samples derived from normal myometrium and uterine leiomyomas obtained from fibroid afflicted patients.Total RNA was extracted from samples, converted to biotin-labeled cRNA, hybridized to oligonucleotide arrays, and followed by model based expression analysis. In order to select differentially expressed genes of interest, dChip model-based expression analysis was employed. Significant genes were identified, utilizing the dChip software, as having an average fold change of > +1.5 or < -1.5 between leiomyoma and normal myometrium and p < 0.05. Under these conditions the 226 genes in the following list were identified. Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS484
Platform:: GPL96
10 Samples

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Series

Accession:: GSE593

ID:: 200000593

Select item 4843.

Uterine fibroid and normal myometrial tissue

Comparison of normal myometrium and uterine leiomyomas obtained from fibroid afflicted patients.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL96
Series:: GSE593
10 Samples

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DataSet

Accession:: GDS484

ID:: 484

Select item 2000413864.

Role of REST in the pathogenesis of uterine fibroids

(Submitter supplied) The loss of REST in uterine fibroids promotes aberrant gene expression and enables mTOR pathway activation

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
9 Samples

Download data: CEL

Series

Accession:: GSE41386

ID:: 200041386

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000052445.

Human Uterine Leiomyomata microRNA gene expression

(Submitter supplied) MicroRNAs (miRNAs) are a class of small, non-coding RNAs. MiRNAs regulate developmental activity and may be aberrantly expressed in human diseases, including cancer. Expression of miRNAs is tissue or organ specific. Human uterine leiomyomas (ULMs) are the most common neoplasms of women, characterized by the ovarian sex hormone dependence, worse morbidity in black women and genetic heterogeneity. The high incidence of the disease may be associated with developmental defects in uteri. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL3879
51 Samples

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Series

Accession:: GSE5244

ID:: 200005244

Select item 2001288986.

PLIN2 knockdown alters the genome-wide gene transcription profile of leiomyoma cells

(Submitter supplied) Purpose: To investigate the function of PLIN2 in human uterine leiomyoma tumorigenesis, we generated genome-wide transcription profile of leiomyoma cells after PLIN2 knockdown. Methods: Primary leiomyoma cells were isolated from fresh uterine leiomyoma tissues and transfected with PLIN2 small interfering RNA (siRNA; 100 nM, #4392422) or non-targeting siRNA (100 nM, #4390844; Ambion, Foster City, CA) for 72 hours. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: TXT

Series

Accession:: GSE128898

ID:: 200128898

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000306737.

Comparison of Gene expression profiles between myometrium, MED12 mutation positive uterine leiomyomas and MED12 wildtype uterine leiomyomas

(Submitter supplied) Gene expression profiles of 10 uterine leiomyomas and their matched normal myometrium specimens were studied using Affymetrix GeneChip Human Genome U133 Plus 2.0 gene expression arrays. Four tumors displayed a codon 44 mutation, four carried a intron 1 mutation, and the remaining two displayed no MED12 mutation.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13916
20 Samples

Download data: CEL

Series

Accession:: GSE30673

ID:: 200030673

Select item 2000316998.

Relationship between Genome-Wide DNA Methylation and Gene Expression in Uterine Leiomyoma

(Submitter supplied) Uterine leiomyomas, or fibroids, represent the most common benign tumor of the female reproductive tract. Fibroids become symptomatic in 30% of all women and up to 70% of African American women of reproductive age. Epigenetic dysregulation of individual genes has been demonstrated in leiomyoma cells; however, the in vivo genome-wide distribution of such epigenetic abnormalities, however, remains unknown. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array

Platforms:: GPL8490 GPL6947
68 Samples

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Series

Accession:: GSE31699

ID:: 200031699

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000128149.

Identifying the molecular signature of the interstitial del(7q) subgroup of uterine leiomyomata using a paired analysis

(Submitter supplied) Uterine leiomyomata (UL), the most common neoplasm in reproductive-age women, have recurrent cytogenetic abnormalities including del(7)(q22q32). To develop a molecular signature, matched del(7q) and non-del(7q) tumors identified by FISH or karyotyping from 11 women were profiled with expression arrays. Our analysis using paired t-tests demonstrates this matched design is critical to eliminate confounding effects of genotype and environment that underlie patient variation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
33 Samples

Download data: CEL

Series

Accession:: GSE12814

ID:: 200012814

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002311210.

Profiling and Functional Analyses of MicroRNAs and Their Target Gene Products in Human Uterine Leiomyomas

(Submitter supplied) Human uterine leiomyomas (ULM) are characterized by dysregulation of a large number of genes and non-coding regulatory microRNAs. In order to identify microRNA::mRNA associations relevant to ULM pathogenesis, we examined global correlation patterns between the altered microRNA expression and the predicted target genes in leiomyomas and matched myometria. We found that some but not all of the predicted and inversely correlated target genes in ULMs can be directly regulated by microRNAs in vitro. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platform:: GPL96
10 Samples

Download data: CEL

Series

Accession:: GSE23112

ID:: 200023112

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001809611.

Identifying the molecular signature of the t(12;14) subgroup of uterine leiomyomata using a paired analysis

(Submitter supplied) Uterine leiomyomata (UL), the most common neoplasm in reproductive age women, have recurrent cytogenetic abnormalities including t(12;14). To develop a molecular signature, matched t(12;14) and non-t(12;14) tumors identified by FISH or karyotyping from each of 9 women were profiled using Affymetrix GeneChip U133 Plus 2.0 oligonucleotide arrays. Model analysis demonstrated the necessity for a matched design to eliminate the confounding effect of genotype and environment that underlay patient to patient variation.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
27 Samples

Download data: CEL

Series

Accession:: GSE18096

ID:: 200018096

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000951112.

Characterization of Plexiform Leiomyomata Provide Further Evidence for Genetic Heterogeneity Underlying Uterine Fibroids

(Submitter supplied) Plexiform leiomyomata are a histologically defined subgroup of benign uterine smooth muscle tumors based on their epitheliod cytology and abundant extracellular matrix. We used microarrays to compare plexiform leiomyomata to normal myometrium (smooth muscle of the uterine wall), typical leiomyomata, cellular or atypical leiomyomata and malignant leiomyosarcoma of the uterus. Keywords: tumor analysis

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL80 GPL570
30 Samples

Download data: CEL, EXP

Series

Accession:: GSE9511

ID:: 200009511

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20019235413.

Integrative analysis of gene expression and DNA methylation reveals epigenetic regulation of tumor suppressor genes and oncogenes involved in uterine leiomyoma pathogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array

Platforms:: GPL21145 GPL24676
124 Samples

Download data: IDAT

Series

Accession:: GSE192354

ID:: 200192354

PubMed Similar studies

Select item 20019235314.

Integrative analysis of gene expression and DNA methylation reveals epigenetic regulation of tumor suppressor genes and oncogenes involved in uterine leiomyoma pathogenesis [Methyl-Seq]

(Submitter supplied) Uterine leiomyomas (UL) are the most common benign tumors in women of reproductive age. Despite the high prevalence, its pathology remains unclear, which hampers the development of safe and effective treatments. Several works have pointed the involvement of epigenetic mechanisms in UL development. Specifically, DNA methylation plays an important role in gene expression regulation. We aim to determine the relationship between DNA methylation and gene expression in UL compared to adjacent myometrium (MM) to describe molecular mechanisms involved in UL formation that are under epigenetic control. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
62 Samples

Download data: CSV, IDAT

Series

Accession:: GSE192353

ID:: 200192353

PubMed Similar studies

Select item 20019235215.

Integrative analysis of gene expression and DNA methylation reveals epigenetic regulation of tumor suppressor genes and oncogenes involved in uterine leiomyoma pathogenesis [RNA-seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
62 Samples

Download data: CSV

Series

Accession:: GSE192352

ID:: 200192352

Select item 20000272516.

The effect of FH mutations on fibroid expression profile 2.

(Submitter supplied) A series of gene expression measurements of normal myometrium and uterine fibroids with mutated or wild-type fumarate hydratase (FH) gene. Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2246
Platform:: GPL96
10 Samples

Download data: CEL, EXP, RPT

Series

Accession:: GSE2725

ID:: 200002725

Select item 20000272417.

The effect of FH mutations on fibroid expression profile, normal myometrium vs. FH-mutant fibroids.

(Submitter supplied) A series of gene expression measurements of uterine fibroids with mutated fumarate hydratase (FH) gene and normal myometrium. Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2245
Platform:: GPL96
18 Samples

Download data: CEL, EXP, RPT

Series

Accession:: GSE2724

ID:: 200002724

Select item 20000215218.

The effect of FH mutations on fibroid expression profile

(Submitter supplied) A series of gene expression measurements of uterine fibroids with mutated or wild-type fumarate hydratase (FH) gene. Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1476
Platform:: GPL96
22 Samples

Download data: CEL, EXP, RPT

Series

Accession:: GSE2152

ID:: 200002152

Select item 224619.

Uterine fibroids with mutated fumarate hydratase (II)

Analysis of uterine fibroids with mutations in the fumarate hydratase (FH) gene. FH catalyzes the hydration of fumarate in the TCA cycle. Heterozygous germline mutations in FH cause uterine fibroids and renal cell cancer. Results provide insight into the pathogenesis of TCA cycle-related tumors.