GEO DataSets

(Submitter supplied) Tissue was microdissected from 13 regions, including 9 distinct neocortical areas, from both left and right sides of four late second trimester human brain specimens. Gene- and exon-level differential expression analyses were performed by mixed model, nested analysis of variance using the XRAY software from Biotique Systems. Further details available in Johnson, Kawasawa, et al., "Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis" Neuron, Volume 62, Issue 4, 2009 Keywords: gene- and exon-level analyses

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5188 GPL5175

190 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Macaca mulatta; Homo sapiens; Pan troglodytes

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

5 related Platforms

92 Samples

Download data: CEL, TXT

(Submitter supplied) We identified human-specific gene expression patterns in the brain by comparing expression with chimpanzee and rhesus macaque.

Organism:

Pan troglodytes; Macaca mulatta; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL9378 GPL9115 GPL9160

44 Samples

Download data: TXT

(Submitter supplied) We identified human-specific gene expression patterns in the brain by comparing expression with chimpanzee and rhesus macaque

Organism:

Pan troglodytes; Homo sapiens; Macaca mulatta

Type:

Expression profiling by array

Platforms:

GPL570 GPL3535

48 Samples

Download data: CEL, TXT

(Submitter supplied) To unravel the gene expression changes during postnatal prefrontal cortex development, RNA-seq was performed in the rat medial prefrontal cortex at five time points from early life to adulthood (postnatal day 8, 14, 21, 35 and 70) and differential expression of protein-coding genes, lincRNAs and alternative exons was analyzed. A switch from neuronal network development to maintenance during postnatal rat prefrontal cortex development was shown.

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:

GPL14844

25 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) Background Alternative splicing is known to increase the complexity of mammalian transcriptomes since nearly all mammalian genes express multiple pre-mRNA isoforms. However, our knowledge of the extent and function of alternative splicing in early embryonic development is based mainly on a few isolated examples. High throughput technologies now allow us to study genome-wide alternative splicing during mouse development. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6096 GPL6193

50 Samples

Download data: CEL

(Submitter supplied) Mutations in FOXP2, a member of the forkhead family of transcription factors, are the only known cause of developmental speech and language disorders in humans. To date, there are no known targets of human FOXP2 in the nervous system. The identification of FOXP2 targets in the developing human brain therefore provides a unique tool with which to explore the development of human language and speech. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL5630

8 Samples

Download data

(Submitter supplied) Gene expression profiling has provided critical insights into the molecular pathways underlying development of model organisms, however little information is available on regulated gene expression during human embryogenesis. We have now filled this important gap of knowledge by performing genome-wide microarray analysis of the Homo sapiens gene expression during the 4-9th week, a period when most organs develop. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

18 Samples

Download data: CEL

(Submitter supplied) The cerebral cortex underwent a rapid expansion and complexification during recent primate evolution, but the underlying developmental mechanisms remain essentially unknown. In order to uncover genetic networks underlying the development of the human cerebral cortex, we profiled the transcriptome of human fetal cortical domains containing language areas of Broca and Wernicke, as well as associative areas. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4532

Platform:

GPL570

8 Samples

Download data: CEL

Analysis of prefrontal/orbito-frontal and parieto-temporal cortex at 17 and 19 gestational weeks. These cortical regions contain presumptive Broca and Wernicke language areas. Results provide insight into molecular mechanisms underlying development of human-specific features of the cerebral cortex.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 development stage, 2 other, 2 tissue sets

Platform:

GPL570

Series:

GSE21858

8 Samples

Download data: CEL

(Submitter supplied) Using RNA interference, we dorsalized and ventralized Nasonia embryos. By comparing transcriptomes from the RNAi cases to each other and to controls, we identify >100 genes expressed along the embryonic DV axis

Organism:

Nasonia vitripennis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16488

6 Samples

Download data: FA, FPKM_TRACKING, TXT

(Submitter supplied) The development of the human brain is a complex and precisely regulated process that unfolds over a protracted period of time. Human-specific features of this process, especially the ways in which highly complex neural circuits of the cerebral cortex form, are likely to be important factors in the evolution of human specializations. However, in addition to giving us remarkable cognitive and motor abilities, the formation of intricate neural circuits may have also increased our susceptibility to psychiatric and neurodegenerative disorders. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5188 GPL5175

2680 Samples

Download data: CEL, CSV, PDF

(Submitter supplied) Amniotic fluid was colelcted during midtrimester from 30 women and at term gestation from 68 women. Cell free RNA was profiled by HTA 2.0 arrays to study the effect of gestational age and other relevant convariates on gene expression and splicing during normal pregnancy.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17586

98 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Glycine max

Type:

Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:

GPL19246

36 Samples

Download data: TXT

(Submitter supplied) Profiling the transcriptome, spliceome, and methylome of developing soybean nodules reveals insights into their associations that may configure transcriptome complexity and proteome diversity

Organism:

Glycine max

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19246

18 Samples

Download data: TXT

(Submitter supplied) Profiling the transcriptome, spliceome, and methylome of developing soybean nodules reveals insights into their associations that may configure transcriptome complexity and proteome diversity

Organism:

Glycine max

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL19246

18 Samples

Download data

(Submitter supplied) Exposure to maternal diabetes during pregnancy alters transcriptional profiles in the developing embryo. The enrichment, within the set of de-regulated genes, of those encoding transcriptional regulatory molecules provides support for the hypothesis that maternal diabetes affects specific developmental programs. We compared E10.5 cntrol embryos to E10.5 embryos from diabetic pregnancies in the FVB mouse strain.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4590

Platform:

GPL1261

6 Samples

Download data: CEL

(Submitter supplied) Diabetic embryopathy can affect any developing organ system, although cardiovascular malformations, neural tube defects and caudal dysgenesis syndrome are the most prominent congenital malformations. We hypothesize that the metabolic imbalance occurring in diabetic pregnancy de-regulates tissue specific gene expression programs in the developing embryo. In order to identify genes whose expression is affected by maternal diabetes, we analyzed gene expression profiles of diabetes-exposed mouse embryos by using Affymetrix microarrays. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4028

Platform:

GPL339

7 Samples

Download data: CEL, CHP

Analysis of embryonic day 10.5 (E10.5) embryos collected from streptozotocin-induced diabetic FVB females. Maternal diabetes is a known risk factor for birth defects. Results provide insight into molecular mechanisms underlying developmental abnormalities of embryos of diabetic pregnancies.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL1261

Series:

GSE41095

6 Samples

Download data: CEL

Analysis of diabetes-exposed, E10.5 whole embryos. Diabetes was induced in FVB females (aged 7-9 wks) by streptozotocin. Maternal diabetes is a well-known risk factor for birth defects, such as neural tube defects. Results provide insight into the causative molecular mechanisms in developing embryo.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state, 2 stress sets

Platform:

GPL339

Series:

GSE9675

7 Samples

Download data: CEL, CHP