GEO DataSets

(Submitter supplied) Rats were given pulmonary embolism by i.v. injection of 25 micron polystyrene microspheres or 0.01% Tween20 solution as vehicle control Embolism of microspheres is irreversible and causes dose dependent pulmonary hypertension Keywords: time course and dose response

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

22 Samples

Download data: CEL, CHP

(Submitter supplied) Time and dose related expression profiles of rat right heart tissue in microsphere bead model for Pulmonary embolism Keywords: Time course and dose response in experimental PE

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3414

Platform:

GPL1355

45 Samples

Download data: CEL

Analysis of right ventricles (RV) of animals for up to 18 hours after injection with polystyrene microsphere beads to induce pulmonary embolism (PE). Animals injected with 1.3 or 2.0 million microspheres/100g body weight. Results provide insight into the mechanisms leading to RV failure after PE.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 3 dose, 3 time sets

Platform:

GPL1355

Series:

GSE6104

45 Samples

Download data: CEL

(Submitter supplied) Pulmonary vascular occlusions due to thromboemboli can result in pulmonary hypertension and right heart damage. Treatments to clear the vascular obstructions such as i.v. heparain or thrombolytics can resolve the hypertension but right ventricular damage often occurs first. Methods of protecting the right ventricle from hypertensive damage during the course of acute treatment to clear the thromboemboli are needed. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

20 Samples

Download data: CEL, CHP

(Submitter supplied) Patients with inflammatory lung diseases are often additionally exposed to polycyclic aromatic hydrocarbons like B[a]P and B[a]P-induced alterations in gene expression in these patients may contribute to the development of lung cancer. Mice were intra-nasally treated with lipopolysaccharide (LPS, 20 μg/mouse) to induce pulmonary inflammation and subsequently exposed to B[a]P (0.5 mg/mouse) by intratracheal instillation We used RNA microarrays to detail the global gene expression change after each treatment. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL20837

15 Samples

Download data: CEL

(Submitter supplied) Mice were aspirated with multiwalled carbon nanotubes in four doses ranging from 10 µg to 80 µg, plus control, and sacrificed after 1, 7, 28, and 56 days. RNA was extracted from the lungs and expression profilling by microarray was performed.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

160 Samples

Download data: TXT

(Submitter supplied) cDNA microarray study of gene expression changes in whole blood from LPS treated rats, 2 and 6 hours after I.P. injection of 5 mg/kg Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1344

12 Samples

Download data: TIFF