GEO DataSets

(Submitter supplied) By directly comparing gene expression in wild type, domestic, and GH transgenic strains of salmon, we have found that domestication and GH transgenesis are modifying similar genetic pathways. Genes in many different physiological pathways show modified expression in domestic and GH transgenic strains relative to wild-type, but effects are strongly correlated. Genes specifically involved in growth regulation (IGF-I, GHR, IGF-II, THR) are also concordantly regulated in domestic and transgenic fish, and both strains show elevated levels of circulating IGF-I. more...

Organism:

Oncorhynchus kisutch; Oncorhynchus mykiss; Oncorhynchus tshawytscha; Osmerus mordax; Salmo salar; Coregonus clupeaformis

Type:

Expression profiling by array

Platform:

GPL2716

29 Samples

Download data: TXT

(Submitter supplied) Growth rate can be genetically modified in many vertebrates by domestication and selection, and more recently by transgenesis overexpressing growth factor genes (e.g. growth hormone, GH). While the phenotypic end consequence is similar, it is currently not clear whether the same modifications to physiological pathways are occurring in both genetic processes, nor to what extent they may interact when combined. more...

Organism:

Salmo salar; Coregonus clupeaformis; Osmerus mordax; Oncorhynchus mykiss; Oncorhynchus tshawytscha

Type:

Expression profiling by array

Platform:

GPL2716

30 Samples

Download data: TXT

(Submitter supplied) This is the first use of cDNA microarrays to study the influence of GH transgenesis on liver gene expression in a non-mammalian vertebrate. Three groups of salmon were examined: transgenic on full ration (T), transgenic on restricted ration (R), and control nontransgenic (C). Daily weight gains in T were approximately 8-fold higher than in C, and 4-fold higher than in R. Differential gene expression in T, R, and C samples was determined using ~ 16,000 gene microarrays. more...

Organism:

Salmo salar; Oncorhynchus kisutch

Type:

Expression profiling by array

Platform:

GPL2989

6 Samples

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(Submitter supplied) The influence of GH transgenesis on liver gene expression in coho salmon was examined. Gene expression in livers of transgenic salmon on a restricted ration (R) was compared to that in livers of nontransgenic control salmon (C). Keywords: Transcript profile

Organism:

Salmo salar

Type:

Expression profiling by array

Platform:

GPL2844

8 Samples

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(Submitter supplied) Coho Salmon GH Transgenic Study Keywords: other

Organism:

Salmo salar; Oncorhynchus kisutch; Oncorhynchus mykiss

Type:

Expression profiling by array

Platform:

GPL966

9 Samples

Download data: TIFF

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Salmo salar; Coregonus clupeaformis; Osmerus mordax; Oncorhynchus mykiss; Oncorhynchus tshawytscha

Type:

Expression profiling by array

Platform:

GPL2716

44 Samples

Download data: TXT

(Submitter supplied) Domestication has produced faster-growing strains of animals for use in agriculture, but selection has been applied with little knowledge of the underlying genetic changes that arose throughout the process. Mammals and birds have been domesticated for thousands of years whereas fish have been domesticated only recently; therefore, wild progenitor strains remain for comparison. Rainbow trout (Oncorhynchus mykiss) have undergone intensive selection and domesticated strains grow more rapidly than extant wild strains. more...

Organism:

Salmo salar; Oncorhynchus tshawytscha; Coregonus clupeaformis; Osmerus mordax; Oncorhynchus mykiss

Type:

Expression profiling by array

Platform:

GPL2716

12 Samples

Download data: TXT

(Submitter supplied) Domestication has produced faster-growing strains of animals for use in agriculture, but selection has been applied with little knowledge of the underlying genetic changes that arose throughout the process. Mammals and birds have been domesticated for thousands of years whereas fish have been domesticated only recently; therefore, wild progenitor strains remain for comparison. Rainbow trout (Oncorhynchus mykiss) have undergone intensive selection and domesticated strains grow more rapidly than extant wild strains. more...

Organism:

Oncorhynchus tshawytscha; Oncorhynchus mykiss; Salmo salar; Osmerus mordax; Coregonus clupeaformis

Type:

Expression profiling by array

Platform:

GPL2716

14 Samples

Download data: TXT

(Submitter supplied) Domestication has produced faster-growing strains of animals for use in agriculture, but selection has been applied with little knowledge of the underlying genetic changes that arose throughout the process. Mammals and birds have been domesticated for thousands of years whereas fish have been domesticated only recently; therefore, wild progenitor strains remain for comparison. Rainbow trout (Oncorhynchus mykiss) have undergone intensive selection and domesticated strains grow more rapidly than extant wild strains. more...

Organism:

Coregonus clupeaformis; Osmerus mordax; Oncorhynchus mykiss; Salmo salar; Oncorhynchus tshawytscha

Type:

Expression profiling by array

Platform:

GPL2716

18 Samples

Download data: TXT