Similar studies for GEO DataSets (Select 200013974) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Links from GEO DataSets

Items: 2

Select item 2000139741.

Genetic inactivation of serine racemase produces behavioral phenotypes related to schizophrenia in mice

(Submitter supplied) Abnormal N-methyl-D-aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. D-serine is an important NMDAR modulator, and to elucidate the role of the D-serine synthesis enzyme serine racemase (Srr) in schizophrenia, we identified and characterized mice with an ENU-induced mutation that results in a complete loss of Srr activity and drastically reduced D-serine levels. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
24 Samples

Download data: TIFF, TXT

Series

Accession:: GSE13974

ID:: 200013974

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001288042.

Serine racemase is required for colorectal tumor growth and a potential therapeutic target.

(Submitter supplied) Serine racemase (SRR) is an enzyme that catalyzes two reactions, the racemization and the dehydration of L-Ser and D-Ser and has been studied mainly in the fields of central nervous system. The function of SRR in cancer metabolism has not been elucidated. Here we show that SRR expression is upregulated in colorectal adenoma and adenocarcinoma lesions compared to non-neoplastic mucosa in human colorectal cancer specimens. more...