GEO DataSets

(Submitter supplied) This study analyzed gene expression of rat peripheral blood mononuclear cells by microarray analysis following different feeding conditions (ad libitum feeding, fasting and refeeding) in normoweight (control) and in diet-induced obese rats (cafeteria rats). The aim of this study was to identify genes and biological pathways that were altered by feeding conditions in normoweight and diet-induced obese rats. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL4135

29 Samples

Download data: TXT

(Submitter supplied) Gene expression of rat peripheral blood mononuclear cells was analyzed by microarray analysis in normoweight and in diet-induced obese rats (cafeteria rats). The aim of this study was to identify genes involved in energy homeostasis that are altered in the obese state. Keywords: Dietary treatment, obese-state analysis

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL4135

9 Samples

Download data: TXT

(Submitter supplied) Gene expression studies in peripheral blood mononuclear cells (PBMC) can provide knowledge that would be difficult to obtain using other types of biological samples, as these cells can reflect overall response of the body to a specific stimulus, such as diet. Here, we aimed to study the impact of sustained intake of isocaloric diets with an unbalanced macronutrient proportion (rich in fat or protein) on PBMC gene expression in rats using transcriptomics, to better understand the effects of these diets on metabolism and health. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL4135

18 Samples

Download data: TXT

(Submitter supplied) Analysis of gene expression profiles of epididymal fat from DIO rats We applied a comparative functional genomics approach to evaluate diet-induced obese (DIO) rats as an obesity model Keywords: single time point, comparison control animal vs. diet induced obese animal

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2946

Platform:

GPL1355

15 Samples

Download data: CEL

Comparison of epididymal fat tissues from diet-induced obese (DIO) and lean animals. DIO animals were fed a high fat, high sucrose diet to induce obesity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 individual sets

Platform:

GPL1355

Series:

GSE8700

15 Samples

Download data: CEL

(Submitter supplied) Male 130 day old rat adipose tissue from control and obese rats Keywords: ordered

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS880

Platform:

GPL341

4 Samples

Download data

Expression profiling of visceral adipose tissue of 130 day old adult male Wistars that had been subjected to poor nutrition during fetal development caused by maternal protein restriction. Results indicate that poor fetal nutrition predisposes to visceral obesity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 growth protocol sets

Platform:

GPL341

Series:

GSE1813

4 Samples

Download data

(Submitter supplied) Dietary n-3 polyunsaturated fatty acids can reduce inflammation via a range of mechanisms. This study tested the effect of dietary eicosapentaenoic acid (EPA) on intestinal inflammation using interleukin-10 gene-deficient (Il10-/-) mice. Methods: At 35 days of age, 12 weaned Il10-/- and 12 C57 mice were randomly assigned to one of two modified AIN-76A diets, supplemented with 3.7% purified ethyl esters of either EPA (n-3) or oleic acid (OA, control). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2872

16 Samples

Download data

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) One of the top priorities of the swine industry worldwide is to decrease the susceptibility of its animals to infectious diseases. There is therefore now an increased focus on the production of more “robust” animals, which have lower susceptibility to a broad range of infectious diseases. One general measure of immune competence is the proliferative response of peripheral blood mononuclear cells (PBMC) to mitogenic stimulation. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL14897

24 Samples

Download data: GPR

(Submitter supplied) The aim of this study was to analyze gene response to a 10-week dietary intervention for weight loss in peripheral blood mononuclear cells of overweight/obese male children.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

24 Samples

Download data: CEL

(Submitter supplied) Oxidative stress in adipose tissue and liver has been linked to the development of obesity. NADPH oxidases (NOX) enzymes are a major source of reactive oxygen species (ROS). The current study was designed to determine if NOX2-generated ROS play a role in development of obesity and metabolic syndrome after high fat feeding. Wild type (WT) mice and mice lacking the cytosolic NOX2 activated protein p47phox (P47KO) were fed AIN-93G diets or high fat diets (HFD) containing 45% fat and 0.5% cholesterol for 13 weeks from weaning. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

12 Samples

Download data: CEL

(Submitter supplied) Acute progressive feed restriction (APFR) represents a specific form of caloric restriction in which feed availability is increasingly curtailed over a period of a few days to a few weeks. It is often used for control animals in toxicological and pharmacological studies on compounds causing body weight loss to equalize weight changes between experimental and control groups and thereby, intuitively, to also set their metabolic states to the same phase. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

26 Samples

Download data: CEL, DAT, EXP

(Submitter supplied) The gene expression profiles of chicken whole blood (WB) and peripheral blood mononuclear cells (PBMC) have been characterized and compared by microarray analysis. This study highlights the respective advantages of each blood cell subset and show that whole blood is more suitable for large scale studies and allows for the exploration of biological processes which are so far poorly investigated.

Organism:

Gallus gallus

Type:

Expression profiling by array

Platform:

GPL19630

8 Samples

Download data: TXT

(Submitter supplied) We compared PBMC genomic response to exercise in both early (EB) and late-pubertal boys (LB) Keywords: stress response

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

40 Samples

Download data: CEL

(Submitter supplied) Moderate maternal calorie restriction during lactation protects rat offspring against obesity development in adulthood, due to an improved ability to handle and store excess dietary fuel. We used this model to identify early transcriptome-based biomarkers of metabolic health using peripheral blood mononuclear cells (PBMCs), an easily accessible surrogate tissue, by focusing on molecular markers of lipid handling. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL4135

23 Samples

Download data: TXT

(Submitter supplied) The effect of benzene exposure on peripheral blood mononuclear cell (PBMC) gene expression was examined in a population of shoe-factory workers with well-characterized occupational exposures to benzene. We compared data from two microarray platforms (Illumina and Affymetrix). Keywords: occupational exposure

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS3559 GDS3560 GDS3561

Platforms:

GPL96 GPL97 GPL2700

48 Samples

Download data: CEL, XLS

Analysis of peripheral blood mononuclear cells from shoe factory workers exposed to benzene. Benzene is a leukemogen. Results provide insight into molecular mechanisms of benzene carcinogenicity.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL2700

Series:

GSE9569

16 Samples

Download data

Analysis of peripheral blood mononuclear cells from shoe factory workers exposed to benzene. Benzene is a leukemogen. Results provide insight into molecular mechanisms of benzene carcinogenicity.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL97

Series:

GSE9569

16 Samples

Download data: CEL