GEO DataSets

(Submitter supplied) The aim of this study was to employ a systems-level analysis to elucidate gene expression networks operating in the CD4 T-cell responses which underpin human atopic disease. Keywords: Disease state analysis; T-cell response

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

90 Samples

Download data: CEL

(Submitter supplied) PBMC from house dust mite (HDM) sensitized atopics were cultured in the presence or absence of HDM extract for 24 hours. At the termination of the cultures, CD4 T cells were isolated using immunomagnetic separation. Gene expression was profiled on microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20171

90 Samples

Download data: CEL, TXT

(Submitter supplied) Background: Multiple regulatory mechanisms have been identified employing conventional hypothesis-driven approaches as contributing to allergen-specific immunotherapy outcomes, but understanding of how these integrate to maintain immunological homeostasis is incomplete. Objective: To explore the potential for unbiased systems-level gene co-expression network analysis to advance understanding of immunotherapy mechanisms. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL25487

198 Samples

Download data: CEL, TXT

(Submitter supplied) Severe asthma exacerbations in children requiring hospitalisation are typically associated with viral infection, and occur almost exclusively amongst atopics, but the significance of these comorbidities is unknown. We hypothesised that underlying interactions between immunoinflammatory pathways related to responses to aeroallergen and virus are involved, and that evidence of these interactions is detectable in circulating cells during exacerbations. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3615

Platform:

GPL570

10 Samples

Download data: CEL

Analysis of peripheral blood mononuclear cells of children with acute asthma during exacerbation and at subsequent convalescence. Severe asthma exacerbations in children are associated with viral infection and occur among atopics. Results provide insight into the significance of these comorbidities.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL570

Series:

GSE16032

10 Samples

Download data: CEL

(Submitter supplied) We report RNA-seq data from distinct memory CD4+ T cell subsets in a murine model of allergic asthma.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

12 Samples

Download data: TXT

(Submitter supplied) PBMC from house dust mite (HDM) sensitized atopics with or without asthma (or nonallergic controls) were cultured in the presence or absence of HDM extract for 24 hours. At the termination of the cultures, immunomagnetic separation was performed to purify CD4 T cells. Gene expression was profiled on microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20171

144 Samples

Download data: CEL

(Submitter supplied) Natural killer T (NKT) cells are a distinct lymphocyte lineage thought to operate primarily at the interface between the innate and adaptive immune response. Yet, their unique role in the immune system remains elusive. Whilst NKT cells show high similarities to other cells of the innate and adaptive immune system, they express unique functional features such as rapid, concomitant production of Th1 and Th2 cytokines upon TCR ligation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1868

16 Samples

Download data: TIFF, TXT, XML

(Submitter supplied) Microarray analyses were performed to compare gene expression in cultured mouse Th9, Th2 and Treg cells and resting versus activated Th9 cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS5291 GDS5343

Platform:

GPL7202

12 Samples

Download data: TXT

Analysis of naive CD4+ T cells cultured under T helper type 9 (Th9) conditions for 5 days and activated with anti-CD3 antibody. Th9 cells are a subpopulation of CD4+ effector T cells that secrete high levels of interleukin-9. Results provide insight into the molecular basis of the Th9 phenotype.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol sets

Platform:

GPL7202

Series:

GSE44937

6 Samples

Download data: TXT

Analysis of naive CD4+ T cells cultured under T helper type 9 (Th9), Th2, or Treg conditions for 5 days. Th9 cells are a subpopulation of CD4+ effector T cells that secrete high levels of interleukin-9. Results provide insight into the molecular basis of the Th9 phenotype.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 cell type sets

Platform:

GPL7202

Series:

GSE44937

9 Samples

Download data: TXT