GEO DataSets

(Submitter supplied) It is basically understood that male and female development is initiated by gonad differentiation into either testis or ovary. However, male embryos are reported to develop faster than female during preimplantation, implying sex differences at this stage. To learn more about when sex differentiation begins, we compared the global gene expression pattern of male and female embryos at the blastocyst stage. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL8329 GPL8326

12 Samples

Download data: TXT

(Submitter supplied) Sexual dimorphism in mammals is mostly attributable to sex-related hormonal differences in fetal and adult tissues; however, this may not be the sole determinant. Though genetically-identical for autosomal chromosomes, male and female preimplantation embryos could display sex-specific transcriptional regulation which can only be attributted to the differences in sexual chromosome dosage. We used microarrays to analyze sex-related transcriptional differences at the blastocyst stage.

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL2112

18 Samples

Download data: CEL

(Submitter supplied) Male embryos are reported to develop faster than female in the preimplantation stage. Therefore, male and female embryos can be considered phenotypically different as early as the preimplantation stage. Employing our sexing system of enhanced green fluorescent protein (EGFP) tagging X chromosomes, we compared the global gene expression pattern of male and female embryos at the blastocyst stage using DNA microarray. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL922

6 Samples

Download data

(Submitter supplied) Paternal and maternal epigenomes undergo dramatic changes after fertilization. How this relates to the 3D reorganisation of the parental genomes and their transcription patterns during early development remains unclear. Here we track structural dynamics during early mouse development using allele-specific single cell HiC integrated with transcriptome and chromatin changes, to combine parental features with early gene expression including during imprinted X-chromosome inactivation. more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL17021

1015 Samples

Download data: TXT

(Submitter supplied) Evaluation of the transcriptomic profile of the rabbit embryo along the preimplantation period during in vivo development. Three embryonic stages were used: four cell embryos (H32 post-coïtum); morula (H58 pc) and blastocyst (H90 pc). Keywords: time course rabbit embryo

Organism:

Oryctolagus cuniculus

Type:

Expression profiling by array

Platform:

GPL7019

18 Samples

Download data: TXT

(Submitter supplied) We reprot transcriptome states in mouse blastocyst cultured with various conditons as well as Xist deletion. By comparing the gene expression states of blastocyst grown in different culture conditions with Xist deletion, we identified the differentially expressed genes, which are dependent culture conditions and Xist RNA.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18480

18 Samples

Download data: XLSX

(Submitter supplied) Gene expression profiling of FACS sorted GFP+ve cells from sexed gonads of transgenic pSF1-eGFP mice Keywords: Time course and comparison of sexes

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1724

Platform:

GPL1261

12 Samples

Download data: CEL

Analysis of gonadal somatic cells from male and female embryos at 10.5 and 11.5 days post coitum (dpc), which span the critical period of male sex determination. Results provide insight into sex determination and gonad differentiation, and identify candidate genes for sexual dysgenesis syndromes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 gender sets

Platform:

GPL1261

Series:

GSE3463

12 Samples

Download data: CEL

(Submitter supplied) Maternal imprinting at the Xist gene is essential to achieve paternal allele-specific imprinted X chromosome inactivation (XCI) in female mammals. However, the mechanism underlying the Xist imprinting is unclear. Here we show that the Xist gene is coated with H3K27me3 in mouse oocytes, which persists through preimplantation development. Ectopic removal of H3K27me3 induces maternal Xist expression and maternal XCI, indicating that maternal H3K27me3 is the imprinting mark of Xist.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL17021

8 Samples

Download data: BED, XLSX

(Submitter supplied) There is an inevitable need for combining in vitro and in vivo culture systems during specific developmental time points to facilitate a comprehensive understanding of early embryo development which would yield insights into the molecular pathways controlling early development and to improve our knowledge in regulation of embryonic development. In current study, we aimed to understand the influences of in vitro culture conditions on bovine blastocyst originated in vivo at 2- or 8-cell stagre. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL13226

12 Samples

Download data: TXT

(Submitter supplied) Blastocyst formation is a primordial event of pre-implantation development since it is required for pregnancy establishment and progression. The blastocyst plays a pivotal role because it is the stage at which the embryo is transferred and starts coordinated cross-talks with the mother. It is also the terminal step of pre-implantation developmentbefore transfer; it reflects all stresses the embryo may have faced during the process of in-vitro treatment. more...

Organism:

Bos taurus

Type:

Expression profiling by array

Platform:

GPL11247

9 Samples

Download data: TXT

(Submitter supplied) Whole brain gene expression was examined in the following strains of mice: 1. P0 maternal monosomic 39,Xm females, C57BL/6J x C3H/Paf 2. P0 paternal monosomic 39, Xp females, In(X)/C3H x C57BL/6J 3. P0 normal 40,XX females, In(X)/C3H x C57BL/6J 4. P0 normal 40,XX females, C57BL/6J x C3H/Paf Keywords = imprinting Keywords = mammalian genetics Keywords = X-linked Keywords = brain Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1513

Platform:

GPL81

10 Samples

Download data

Analysis of neonatal brains of X-monosomic females that inherited either a maternal or a paternal X chromosome. X-monosomy is the basis of Turner's syndrome (TS). Expressivity of TS phenotypes depends partly on the parental origin of the single X. This expressivity may be due to imprinted X genes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 genotype/variation, 2 protocol sets

Platform:

GPL81

Series:

GSE1606

10 Samples

Download data

(Submitter supplied) Comparison of mouse ES cells and three different XEN cell cultures. Three XEN cell cultures: Two different strains (IM8A1 is PO, and XEN1-3 is ICR). And two different culture conditions (IM8A1-I versus IM8A1-II). Three biological replicates of XEN cell RNA were submitted to the Centre for Applied Genomics at the Hospital for Sick Children (Toronto, Canada) for preparation of cRNA and hybridization to the mouse U74Av2 Affymetrix gene array. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1763

Platform:

GPL81

4 Samples

Download data: CEL, EXP, RPT

Analysis of blastocyst-derived extra-embryonic endoderm (XEN) cell lines and an embryonic stem (ES) cell line. Results identify independent XEN cell lines that express markers of extra-embryonic endoderm, but not those of the epiblast, and thus represent a new model of an early mammalian lineage.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 cell line, 2 cell type, 3 growth protocol, 3 strain sets

Platform:

GPL81

Series:

GSE2204

4 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we perform allele-specific RNA-Seq on isogenic B6D2F1 mice to assay imprinted genes in tissues from early embryonic stages and in pluripotent cell lines. For the cell lines, we include embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) derived from fertilized embryos or from embryos obtained after nuclear transfer (NT), as well as B6D2F1 ESCs and EpiSCs derived after parthenogenetic activation (PGA). more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL11002 GPL19057 GPL13112

22 Samples

Download data: WIG

(Submitter supplied) During early mammalian development transient pools of pluripotent cells emerge that can be immortalised upon stem cell derivation. The pluripotent state, "naïve" or "primed", depends on the embryonic stage and derivation conditions used. Here we analyse the temporal gene expression patterns of mouse, cattle and porcine embryos at stages that harbour different types of pluripotent cells. We document conserved and divergent traits in gene expression, and identify predictor genes shared across the species that are associated with pluripotent states in vivo and in vitro Amongst these are the pluripotency-linked genes Klf4 and Lin28b The novel genes discovered include naïve- (Spic, Scpep1 and Gjb5) and primed-associated (Sema6a and Jakmip2) genes as well as naïve-to primed transition genes (Dusp6 and Trip6). more...

Organism:

Bos taurus; Sus scrofa; Mus musculus

Type:

Expression profiling by high throughput sequencing

4 related Platforms

34 Samples

Download data: BEDGRAPH, WIG