Similar studies for GEO DataSets (Select 200016738) - GEO DataSets

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Items: 3

Select item 2000167381.

Translational Changes Upon Dietary Restriction in Drosophila

(Submitter supplied) Analysis of the translational changes induced upon DR in male Drosophila.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL1322
12 Samples

Download data: CEL

Series

Accession:: GSE16738

ID:: 200016738

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001061052.

PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

(Submitter supplied) The mitochondrial unfolded protein response (UPRmt) has been associated with long lifespan across metazoans. In Caenorhabditis elegans, mild developmental mitochondrial stress activates UPRmt reporters and extends lifespan. We show that similar developmental stress is necessary and sufficient to extend Drosophila lifespan, and identify Phosphoglycerate Mutase 5 (PGAM5) as a mediator of this response. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16479
11 Samples

Download data: XLSX

Series

Accession:: GSE106105

ID:: 200106105

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000375373.

Intra-myocellular fatty acid synthesis and breakdown plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster

(Submitter supplied) Dietary restriction (DR) is a robust environmental intervention that slows aging in various species. Changes in fat content have been associated with DR, but whether they play a causal role in mediating various responses to DR remains unknown. We demonstrate that upon DR, Drosophila melanogaster shift their metabolism towards increasing both fatty acid synthesis and breakdown. Inhibition of acetyl CoA carboxylase (ACC), a critical enzyme in fatty acid synthesis, or fatty acid oxidation genes specifically in the muscle tissue inhibited the lifespan extension observed upon DR, suggesting a critical role for intra-myocellular fatty acid metabolism. more...