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Links from GEO DataSets

Items: 20

1.

ChIP-chip from mouse male and female adult livers and P12.5 embryos with H3K27me3

(Submitter supplied) The H3K27me3 is a repressive histone mark associated with repressive chromatin and is important for X chromosome inactivation. ChIP-chip of H3K27me3 along the mouse X chromosome in male and female livers and p12.5 embryos demonstrated that H3K27me3 is absent at the genes that escape X inactivation.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL10129
4 Samples
Download data: PAIR, TXT
Series
Accession:
GSE20617
ID:
200020617
2.

Expression profiles of (40,XX) and (39,XO) females

(Submitter supplied) Gobal expression analysis in four somatic tissues (brain, liver, kidney and muscle) of adult 40,XX and 39,XO mice with the aim of identifying which genes are expressed from both X chromosomes as well as those genes deregulated in X chromosome monosomy. Keywords: Expression profiling by array
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3728
Platform:
GPL6105
36 Samples
Download data: TXT
Series
Accession:
GSE13520
ID:
200013520
3.
Full record GDS3728

X chromosome dosage model

Analysis of four somatic tissues (brain, liver, kidney and muscle) from 12-week-old 40,XX and X monosomic (39,XO) mice. In humans, complete or partial monosomy of the X chromosome results in Turner syndrome (45,XO). Genes deregulated in XO mice provide insight into the molecular basis of TS.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 genotype/variation, 4 tissue sets
Platform:
GPL6105
Series:
GSE13520
36 Samples
Download data
4.

Studies of regulation of mouse X inactivation and genes escaping XCI

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Mus musculus x Mus spretus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
9 related Platforms
70 Samples
Download data: BED, BIGWIG, GFF, PAIR, TXT, XLS
Series
Accession:
GSE59779
ID:
200059779
5.

Regulation of mouse X inactivation (ChIP-Seq)

(Submitter supplied) X chromosome inactivation (XCI) silences most genes on one X chromosome in female mammals, but some genes escape XCI. To identify escape gene in vivo and to explore molecular mechanisms that regulate this process we analyzed the allele-specific expression and chromatin structure of X-linked genes in mouse tissues and cells with skewed XCI and distinguishable alleles based on single nucleotide polymorphisms. more...
Organism:
Mus musculus x Mus spretus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL18997 GPL16617
3 Samples
Download data: BED, BIGWIG
Series
Accession:
GSE59778
ID:
200059778
6.

Escape from X inactivation in mouse tissues (RNA-Seq)

(Submitter supplied) X chromosome inactivation (XCI) silences most genes on one X chromosome in female mammals, but some genes escape XCI. To identify escape gene in vivo and to explore molecular mechanisms that regulate this process we analyzed the allele-specific expression and chromatin structure of X-linked genes in mouse tissues and cells with skewed XCI and distinguishable alleles based on single nucleotide polymorphisms. more...
Organism:
Mus musculus x Mus spretus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16617
5 Samples
Download data: TXT
Series
Accession:
GSE59777
ID:
200059777
7.

F1 Interspecies Hybrid Analysis Reveals Parent-Of-Origin Bias in the Mouse Placenta

(Submitter supplied) To investigate the epigenetic landscape at the interface between mother and fetus, we provide a comprehensive analysis of parent of origin bias in the placenta. Using F1 interspecies hybrids, we sequenced RNA from 23 individual midgestation placentas, five late stage placentas, and two yolk sac samples and then used SNPs to determine whether transcripts were preferentially generated from the maternal or paternal allele. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9250
31 Samples
Download data: BED
Series
Accession:
GSE42671
ID:
200042671
8.

Genome-wide characterization of allelic chromatin in human fibroblast and lymphoblastoid cell lines by high-density allele-specific analyses

(Submitter supplied) Cis-regulatory variants are predicted to mediate the majority of the common genetic risk associated to complex disease, yet the specific causal variants have thus far been poorly characterized. Allele-specific (AS) assessment of chromatin modifications has the potential to elucidate specific cis-regulatory mechanisms. However, development of chromatin landscapes at allelic resolution has been challenging since sites of variable signal strength require substantial read depth not commonly applied in next-generation sequencing based approaches. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
4 related Platforms
224 Samples
Download data: TXT
Series
Accession:
GSE51272
ID:
200051272
9.

Genome-wide assessment of imprinted expression in human cells

(Submitter supplied) Parent-of-origin dependent expression of alleles, imprinting, has been suggested to impact a substantial proportion of mammalian genes. Its discovery requires allele-specific detection of expressed transcripts, but in some cases detected allelic expression (AE) bias has been interpreted as imprinting without demonstrating compatible transmission patterns and excluding heritable variation. Therefore, we utilized a genome-wide tool exploiting high density genotyping arrays in parallel measurements of genotypes in RNA and DNA to determine AE across the transcriptome in lymphoblastoid cell lines (LCLs) and skin fibroblasts derived from families.
Organism:
Homo sapiens
Type:
SNP genotyping by SNP array; Genome variation profiling by SNP array
Platforms:
GPL6984 GPL6983
112 Samples
Download data
Series
Accession:
GSE26286
ID:
200026286
10.

H3K27me3 profiles along the length of the X chromosome in trophoblast stem (TS) cells, ChIP-chip

(Submitter supplied) This analysis includes H3K27me3 profiles along the length of the X-chromosome in male (F2) and female (K4) TS cells and in female TS cells showing local reversals of imprinted X-chromosome inactivation (K4GFP). Data also includes H3K27me3 ChIP-chip profiles in Eed-/- mutant male and female TS cells obtained from Magnuson laboratory (Kalantry S. et al., Nat Cell Biol, 2006).
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL14676
10 Samples
Download data: PAIR
Series
Accession:
GSE32655
ID:
200032655
11.

Comparative and integrated functional genomics analysis of Klinefelter and Turner syndromes reveals network-wide effects of the sex chromosome dosage changes

(Submitter supplied) Background: In both Turner syndrome (TS) and Klinefelter syndrome (KS) copy number aberrations of the X chromosome lead to various developmental symptoms. To date there has not been a comprehensive and directly comparative analysis of TS vs. KS regarding the changes on the molecular level Methods: We analyzed gene expression patterns with RNA-Seq and DNA methylation patterns with the CpGiant assay in lymphocytes, and chromatin conformation with in situ Hi-C in lymphoblastoid cell lines, from TS and KS patients together with their same gender controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other
Platforms:
GPL16791 GPL18573 GPL20301
70 Samples
Download data: TSV, TXT
12.

An evaluation of the effects of CRISPR/cas9-mediated editing of the Dxz4 locus on regulation of the mouse inactive X chromosome in Patski cells [RNA-seq]

(Submitter supplied) The mammalian inactive X chromosome (Xi) condenses into a bipartite structure with two superdomains of frequent long-range contacts separated by a boundary or hinge region. Using in situ DNase Hi-C in mouse cells with deletions or inversions within the hinge, we show that the conserved repeat locus Dxz4 alone is sufficient to maintain the bipartite structure and that Dxz4 orientation controls the distribution of long-range contacts on the Xi. more...
Organism:
Mus musculus x Mus spretus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20213
17 Samples
Download data: TSV
Series
Accession:
GSE107291
ID:
200107291
13.

An evaluation of the effects of CRISPR/cas9-mediated editing of the Dxz4 locus on regulation of the mouse inactive X chromosome in Patski cells [ATAC-seq]

(Submitter supplied) The mammalian inactive X chromosome (Xi) condenses into a bipartite structure with two superdomains of frequent long-range contacts separated by a boundary or hinge region. Using in situ DNase Hi-C in mouse cells with deletions or inversions within the hinge, we show that the conserved repeat locus Dxz4 alone is sufficient to maintain the bipartite structure and that Dxz4 orientation controls the distribution of long-range contacts on the Xi. more...
Organism:
Mus musculus x Mus spretus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20213
4 Samples
Download data: BED, XLS
Series
Accession:
GSE107290
ID:
200107290
14.

An evaluation of the effects of CRISPR/cas9-mediated editing of the Dxz4 locus on regulation of the mouse inactive X chromosome in Patski cells [ChIP-seq]

(Submitter supplied) The mammalian inactive X chromosome (Xi) condenses into a bipartite structure with two superdomains of frequent long-range contacts separated by a boundary or hinge region. Using in situ DNase Hi-C in mouse cells with deletions or inversions within the hinge, we show that the conserved repeat locus Dxz4 alone is sufficient to maintain the bipartite structure and that Dxz4 orientation controls the distribution of long-range contacts on the Xi. more...
Organism:
Mus musculus x Mus spretus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20213
6 Samples
Download data: BED, XLS
Series
Accession:
GSE107286
ID:
200107286
15.

An evaluation of the effects of CRISPR/cas9-mediated editing of the Dxz4 locus on regulation of the mouse inactive X chromosome in Patski cells [DNase HiC]

(Submitter supplied) The mammalian inactive X chromosome (Xi) condenses into a bipartite structure with two superdomains of frequent long-range contacts separated by a boundary or hinge region. Using in situ DNase Hi-C in mouse cells with deletions or inversions within the hinge, we show that the conserved repeat locus Dxz4 alone is sufficient to maintain the bipartite structure and that Dxz4 orientation controls the distribution of long-range contacts on the Xi. more...
Organism:
Mus musculus x Mus spretus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20213
6 Samples
Download data: TXT
Series
Accession:
GSE107282
ID:
200107282
16.

Nucleophosmin binding on the mouse X chromosomes

(Submitter supplied) In mammals, one of the female X chromosomes and all imprinted genes are expressed exclusively from a single allele in somatic cells. To evaluate structural changes associated with allelic silencing, we have applied a recently developed Hi-C assay that uses DNase I for chromatin fragmentation to mouse F1 hybrid systems. Results We find radically different conformations for the two female mouse X chromosomes. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL10129
2 Samples
Download data: GFF
Series
Accession:
GSE71903
ID:
200071903
17.

Bipartite structure of the inactive mouse X chromosome

(Submitter supplied) A subset of genomic regions, including one of the female X chromosomes and all imprinted genes, are expressed exclusively from a single allele in somatic cells of mammals. To evaluate structural changes associated with allelic silencing, we used mouse F1 hybrid systems in which X inactivation is skewed and alleles can be distinguished based on single nucleotide polymorphisms to analyze chromatin contacts by a new Hi-C assay that uses DNase I for chromatin fragmentation. more...
Organism:
Mus musculus x Mus spretus
Type:
Other
Platforms:
GPL20213 GPL16616
4 Samples
Download data: TXT
Series
Accession:
GSE68992
ID:
200068992
18.

Female-specific CTCF binding on the inactive X chromosome in mouse

(Submitter supplied) In mammals, genes located on the X chromosome are present in one copy in XY males and two in XX females. To balance the dosage of X-linked gene expression between the sexes one of the two X chromosomes in females is silenced by X inactivation initiated by up-regulation of the lncRNA (long non-coding RNA) Xist and recruitment of specific chromatin modifiers for silencing. The inactivated X chromosome becomes heterochromatic and visits a specific nuclear compartment adjacent to the nucleolus. more...
Organism:
Mus musculus x Mus spretus; Mus musculus
Type:
Genome binding/occupancy profiling by genome tiling array
5 related Platforms
19 Samples
Download data: GFF, PAIR
Series
Accession:
GSE66262
ID:
200066262
19.

Effects of Firre knockdown on mouse gene expression

(Submitter supplied) In mammals, genes located on the X chromosome are present in one copy in XY males and two in XX females. To balance the dosage of X-linked gene expression between the sexes one of the two X chromosomes in females is silenced by X inactivation initiated by up-regulation of the lncRNA (long non-coding RNA) Xist and recruitment of specific chromatin modifiers for silencing. The inactivated X chromosome becomes heterochromatic and visits a specific nuclear compartment adjacent to the nucleolus. more...
Organism:
Mus musculus x Mus spretus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16617
4 Samples
Download data: TXT
Series
Accession:
GSE66172
ID:
200066172
20.

Upregulation of the mammalian X chromosome is associated with enhanced transcription initiation, MOF-mediated H4K16 acetylation, and longer RNA half-life

(Submitter supplied) Many animal species employ a chromosome-based mechanism of sex determination, which has led to coordinate evolution of dosage compensation systems. Dosage compensation not only corrects the imbalance in the number of X-chromosomes between the sexes, but is also hypothesized to correct dosage imbalance within cells due to mono-allelic X expression and bi-allelic autosomal expression, by upregulating X-linked genes (termed ‘Ohno’s hypothesis’). more...
Organism:
Mus musculus; Mus musculus x Mus spretus
Type:
Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL16733 GPL10129 GPL16143
25 Samples
Download data: PAIR
Series
Accession:
GSE44835
ID:
200044835
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