GEO DataSets

(Submitter supplied) Diabetes mellitus, obesity, and dyslipidemia increase risk for cardiovascular disease, and expose the heart to high plasma fatty acid (FA) levels. Recent studies suggest that distinct FA species are cardiotoxic (e.g., palmitate), while others are cardioprotective (e.g., oleate), although the molecular mechanisms mediating these observations are unclear. The purpose of the present study was to investigate the differential effects of distinct FA species (varying carbon length and degree of saturation) on adult rat cardiomyocyte (ARC) gene expression. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3648

Platform:

GPL10239

46 Samples

Download data: TXT

Analysis of cardiomyocytes treated with 0.4 mM octanoate, palmitate, stearate, oleate, or linoleate for 24 hours. Studies suggest that distinct fatty acid species are cardiotoxic, while others are cardioprotective. Results provide insight into the molecular basis of these effects on the heart.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 6 agent sets

Platform:

GPL10239

Series:

GSE21023

46 Samples

Download data

(Submitter supplied) To identify mediators of obesity-linked reductions in PGC-1, we tested the effects of cellular nutrients in C2C12 myotubes. While overnight exposure to high insulin, glucose, glucosamine, or amino acids had no effect, saturated fatty acids (FA) potently reduced PGC-1a and b mRNA expression. Keywords: Nutrient Effect

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2648

Platform:

GPL8321

6 Samples

Download data: CEL

Analysis of myoblasts treated with the saturated fatty acid palmitate. Muscle expression of PPAR coactivator 1 (PGC-1) is reduced in models of obesity. Palmitate decreases the expression of PGC-1. Results provide insight into the molecular basis of the link between overnutrition, obesity, and PGC-1.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL8321

Series:

GSE6766

6 Samples

Download data: CEL