GEO DataSets

(Submitter supplied) Although short-term disuse does not result in measurable muscle atrophy, studies suggest that molecular changes associated with protein degradation may be initiated within days of the onset of a disuse stimulus. We examined the global gene expression patterns in sedentary men (n = 7, mean age ± S.D = 22.1 ± 3.7 yr) following 48h unloading (UL) via unilateral lower limb suspension and 24h reloading (RL). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3762

Platform:

GPL570

21 Samples

Download data: CEL, CHP

(Submitter supplied) Following spinal cord injury, skeletal muscle loss is rapid. This severe atrophy is attributed to declines in protein synthesis and increases in protein breakdown. However, the signaling mechanisms controlling these changes are not well understood. Nine male patients and one female patient with spinal cord injury (SCI) (Mean ± SEM = 43.9 ± 6.7 yrs) were recruited for this study. Six patients were quadriplegics and four patients were paraplegics. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

20 Samples

Download data: CEL, CHP

Analysis of left vastus lateralis muscle biopsies from 7 sedentary men following unloading (48 hr) via unilateral lower limb suspensionand and subsequent reloading (24 hr). Results provide insight into molecular events underlying the earliest stages of skeletal muscle disuse and reambulation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 7 individual, 3 protocol sets

Platform:

GPL570

Series:

GSE21496

21 Samples

Download data: CEL, CHP

(Submitter supplied) The present study concerns the effects of 21 days of sustained recumbence (bedrest) on skeletal muscle gene expression. 14 male subjects participated in normoxic bedrest (NBR) with muscle unloading, for 21 days, this is a substudy of tha PlanHab-study which apart from normoxic bedrest also involved hyboxic bedrest and hypoxic ambulation Throughout both bedrest interventions, each subject remained in a horizontal position at all times. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17692

24 Samples

Download data: CEL

(Submitter supplied) Spaceflight results in a number of adaptations to skeletal muscle, including atrophy and shifts towards faster muscle fiber types. To identify changes in gene expression that may underlie these adaptations, microarray expression analysis was performed on gastrocnemius from mice flown on the STS-108 shuttle flight (11 days, 19 hours) versus mice maintained on earth for the same period. Additionally, to identify changes that were due to unloading and reloading, microarray analyses were conducted on calf muscle from ground-based mice subjected to hindlimb suspension (12 days) and mice subjected to hindlimb suspension plus a brief period of reloading (3.5 hours) to simulate the time between landing and sacrifice of the spaceflight mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

23 Samples

Download data: CEL

(Submitter supplied) Breaking up prolonged sitting has been shown to be beneficially associated with cardio-metabolic risk markers in both observational and intervention studies. We aimed to define the acute transcriptional events induced in skeletal muscle by breaks in sedentary time. Overweight/obese adults participated in a randomized three-period, three-treatment cross-over trial in an acute setting (5 hours): seated position with no activity, seated with 2-minute bouts of light- or moderate-intensity treadmill walking every 20 minutes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

24 Samples

Download data: TXT

(Submitter supplied) Our results suggest that 48h of immobilization increases expression of mRNA for components of the UPP and MT function while decreasing mRNA and protein for components involved in ECM integrity. We hypothesized that 48h of immobilization would increase gene expression and respective protein products for components of the ubiquitin proteasome pathway (UPP). Keywords: stimulus or stress design

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2083

Platform:

GPL570

10 Samples

Download data: CEL

Analysis of vastus lateralis muscle after knee immobilization for 48 hours. Limbs immobilized due to injury or illness experience significant muscle atrophy within 1 or 2 weeks. Results provide insight into the mechanisms regulating the rapid protein degradation in immobilized skeletal muscles.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 individual, 2 stress sets

Platform:

GPL570

Series:

GSE5110

10 Samples

Download data: CEL

(Submitter supplied) To help elucidate mechanistic differences between lengthening and shortening muscle contractions we compared changes in gene expression within 24 h of an acute bout of each type of contraction in the quadriceps. Three healthy young men performed shortening contractions with one leg while the contralateral leg performed lengthening contractions. Biopsies were taken from both legs before exercise, 3, 6, and 24 h afterwards. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2740

Platform:

GPL246

24 Samples

Download data: CEL

Analysis of skeletal muscles at various time points up to 24 hours after acute bouts of either lengthening (LCs) or shortening contractions (SCs). Resistance training using LCs results in greater increases in muscle size than SCs. Results provide insight into the molecular basis of this difference.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 individual, 2 protocol, 4 time sets

Platform:

GPL246

Series:

GSE7286

24 Samples

Download data: CEL

(Submitter supplied) The goal of this study was to identify changes in muscle gene expression that may contribute to loss of adaptability of old muscle. Muscle atrophy was induced in young adult (6-month) and old (32-month) male Brown Norway/F344 rats by two weeks of hind limb suspension (HS) and soleus muscles were analyzed by cDNA microarrays. We conclude that a cold shock response may be part of a compensatory mechanism in muscles undergoing atrophy to preserve remaining muscle mass and that RBM3 may be a therapeutic target to prevent muscle loss.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7045

18 Samples

Download data: CSV

(Submitter supplied) vastus lateralis biopsies were obtained from healthy subjects, either young adults (20-29 yr old) or older (65-75 yr old) Keywords = muscle Keywords = aging Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS287 GDS288

Platforms:

GPL96 GPL97

30 Samples

Download data

Comparison of gene expression in vastus lateralis skeletal muscle biopsies in healthy young (21-27 year old) and older (67-75 year old) men.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL97

Series:

GSE362

15 Samples

Download data

Comparison of gene expression in vastus lateralis skeletal muscle biopsies in healthy young (21-27 year old) and older (67-75 year old) men

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL96

Series:

GSE362

15 Samples

Download data

(Submitter supplied) Microgravity exposure as well as chronic muscle disuse are two of the main causes of physiological adaptive skeletal muscle atrophy in humans and murine animals in physiological condition. The aim of this study was to investigate, at both morphological and global gene expression level, skeletal muscle adaptation to microgravity in mouse soleus and extensor digitorum longus (EDL). Adult male mice C57BL/N6 were flown aboard the BION-M1 biosatellite for 30 days on orbit (BF) or housed in a replicate flight habitat on Earth (BG) as reference flight control. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

18 Samples

Download data: CEL

(Submitter supplied) Massage therapy is commonly used for the physical rehabilitation of skeletal muscle to ameliorate pain and promote recovery from injury. While there is some evidence that massage may relieve pain in injured muscle, the cellular effects remain unknown. To assess the effects of massage, we administered either massage therapy or no treatment to separate quadriceps of eleven young, male participants after exercised-induced muscle damage. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL14871

55 Samples

Download data: PAIR

(Submitter supplied) To further unravel the potential molecular mechanisms involved in the loss of muscle function during an acute exacerbation, a cross-sectional microarray study was designed to compare the gene expression profile of the vastus lateralis muscle in patients with an acute COPD exacerbation and in stable COPD patients. Keywords: cross-sectional patient study

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2891

9 Samples

Download data

(Submitter supplied) Gene expression data of micro RNA from skeletal muscle sample of pig breed Duroc and Pietrain at adult stage.

Organism:

synthetic construct; Sus scrofa

Type:

Non-coding RNA profiling by array

Platform:

GPL16384

20 Samples

Download data: CEL

(Submitter supplied) Advancements in animal models and cell culture techniques have been invaluable in the elucidation of molecular events and mechanisms regulating muscle atrophy. However, few studies have examined muscle atrophy in humans using modern experimental techniques. The purpose of this study was to examine and validate changes in global gene transcription during immobilization-induced muscle atrophy in humans. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

72 Samples

Download data

(Submitter supplied) Acute quadriplegic myopathy (AQM) or critical illness myopathy (CIM) is frequently observed in intensive care unit (ICU) patients. In order to elucidate duration-dependent effects of the ICU intervention on molecular and functional networks that control the muscle wasting and weakness in AQM, gene expression profile was analyzed at time points varying from 6 hours to 14 days in a unique experimental rat model mimicking ICU conditions, i.e., post-synaptically paralyzed, mechanically ventilated and extensively monitored animals.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

28 Samples

Download data: CEL, TXT